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Title: | Combating virulence of Gramnegative bacilli by OmpA inhibition |
Author: | Vila Farrés, Xavier Parra Millán, Raquel Sánchez Encinales, Viviana Varese, Monica Ayerbe Algaba, Rafael Bayó Puxan, Núria Guardiola Bagán, Salvador Pachón Ibáñez, María Eugenia Kotev, Martin García Arroyo, Jesús Teixidó Turà, Meritxell Vila Estapé, Jordi Pachón, Jerónimo Giralt Lledó, Ernest Smani, Younes |
Keywords: | Bacteris gramnegatius Malalties bacterianes Gram-negative bacteria Bacterial diseases |
Issue Date: | 31-Oct-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-14972-y |
It is part of: | Scientific Reports, 2017, vol. 7, num. 14683 |
URI: | http://hdl.handle.net/2445/122399 |
Related resource: | https://doi.org/10.1038/s41598-017-14972-y |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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