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http://hdl.handle.net/2445/122570
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DC Field | Value | Language |
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dc.contributor.author | Font, Joan | - |
dc.contributor.author | López-Cano, Marc | - |
dc.contributor.author | Notartomaso, Serena | - |
dc.contributor.author | Scarselli, Pamela | - |
dc.contributor.author | Di Pietro, Paola | - |
dc.contributor.author | Bresolí-Obach, Roger | - |
dc.contributor.author | Battaglia, Giuseppe | - |
dc.contributor.author | Malhaire, Fanny | - |
dc.contributor.author | Rovira, Xavier | - |
dc.contributor.author | Catena, Juanlo | - |
dc.contributor.author | Giraldo, Jesús | - |
dc.contributor.author | Pin, Jean-Philippe | - |
dc.contributor.author | Fernández Dueñas, Víctor | - |
dc.contributor.author | Goudet, Cyril | - |
dc.contributor.author | Nonell, Santi | - |
dc.contributor.author | Nicoletti, Ferdinando | - |
dc.contributor.author | Llebaria Soldevila, Amadeu | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2018-05-25T07:57:00Z | - |
dc.date.available | 2018-05-25T07:57:00Z | - |
dc.date.issued | 2017-04-11 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/2445/122570 | - |
dc.description.abstract | Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator raseglurant. Violet light illumination of JF-NP-26 induces a photochemical reaction prompting the active-drug's release, which effectively controls mGlu5 receptor activity both in ectopic expressing systems and in striatal primary neurons. Systemic administration in mice followed by local light-emitting diode (LED)-based illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflammatory pain models. These data offer the first example of optical control of analgesia in vivo using a photocaged mGlu5 receptor negative allosteric modulator. This approach shows potential for precisely targeting, in time and space, endogenous receptors, which may allow a better management of difficult-to-treat disorders. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.7554/eLife.23545 | - |
dc.relation.ispartof | eLife, 2017, vol. 6, p. e23545 | - |
dc.relation.uri | https://doi.org/10.7554/eLife.23545 | - |
dc.rights | cc-by (c) Font, Joan et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Neurociències | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.classification | Farmacologia | - |
dc.subject.classification | Tractament del dolor | - |
dc.subject.other | Neurosciences | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.subject.other | Pharmacology | - |
dc.subject.other | Pain treatment | - |
dc.title | Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 679441 | - |
dc.date.updated | 2018-05-25T07:57:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28395733 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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679441.pdf | 2.5 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License