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http://hdl.handle.net/2445/122634
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DC Field | Value | Language |
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dc.contributor.author | Navarro Brugal, Gemma | - |
dc.contributor.author | Quiroz, César | - |
dc.contributor.author | Moreno-Delgado, David | - |
dc.contributor.author | Sierakowiak, Adam | - |
dc.contributor.author | McDowell, Kimberly | - |
dc.contributor.author | Moreno Guillén, Estefanía | - |
dc.contributor.author | Rea, William | - |
dc.contributor.author | Cai, Ning-Sheng | - |
dc.contributor.author | Aguinaga Andrés, David | - |
dc.contributor.author | Howell, Lesley A. | - |
dc.contributor.author | Hausch, Felix | - |
dc.contributor.author | Cortés Tejedor, Antonio | - |
dc.contributor.author | Mallol Montero, Josefa | - |
dc.contributor.author | Casadó, Vicent | - |
dc.contributor.author | Lluís i Biset, Carme | - |
dc.contributor.author | Canela Campos, Enric I. | - |
dc.contributor.author | Ferré, Sergi | - |
dc.contributor.author | McCormick, Peter J. | - |
dc.date.accessioned | 2018-05-29T11:40:04Z | - |
dc.date.available | 2018-05-29T11:40:04Z | - |
dc.date.issued | 2015-04-29 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122634 | - |
dc.description.abstract | Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior. We provide evidence for pharmacologically significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor (CRF1R) and orexin OX1 receptors (OX1R). CRF1R-OX1R heteromers are the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells and rat VTA, in which they significantly modulate dendritic dopamine release. The cocaine target sigma1 receptor (sigma1R) also associates with the CRF1R-OX1R heteromer. Cocaine binding to the sigma1R-CRF1R-OX1R complex promotes a long-term disruption of the orexin-A-CRF negative crosstalk. Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The Society for Neuroscience | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.4364-14.2015 | - |
dc.relation.ispartof | Journal of Neuroscience, 2015, vol. 35, num. 17, p. 6639-6653 | - |
dc.relation.uri | https://doi.org/10.1523/JNEUROSCI.4364-14.2015 | - |
dc.rights | cc-by-nc-sa (c) Navarro Brugal, Gemma et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Cocaïna | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | Cocaine | - |
dc.title | Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 652895 | - |
dc.date.updated | 2018-05-29T11:40:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25926444 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Bioquímica i Fisiologia) |
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652895.pdf | 3.74 MB | Adobe PDF | View/Open |
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