Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/122905
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moisés, Jorge | - |
dc.contributor.author | Navarro Ponz, Alfons | - |
dc.contributor.author | Santasusagna, Sandra | - |
dc.contributor.author | Viñolas Segarra, Núria | - |
dc.contributor.author | Molins López-Rodó, Laureano | - |
dc.contributor.author | Ramirez, José | - |
dc.contributor.author | Osorio, Jeisson | - |
dc.contributor.author | Saco, Adela | - |
dc.contributor.author | Castellano, Joan Josep | - |
dc.contributor.author | Muñoz García, Carmen | - |
dc.contributor.author | Morales, Sara | - |
dc.contributor.author | Monzó Planella, Mariano | - |
dc.contributor.author | Marrades Sicart, Ramon Ma. | - |
dc.date.accessioned | 2018-06-12T10:59:36Z | - |
dc.date.available | 2018-06-12T10:59:36Z | - |
dc.date.issued | 2017-12-13 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122905 | - |
dc.description.abstract | BACKGROUND: NKX2-1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role of NKX2-1 in NSCLC have reported contradictory findings. Two microRNAs (miRNAs) have been associated with NKX2-1: miR-365, which targets NKX2-1; and miR-33a, which is downstream of NKX2-1. We have examined the effect of NKX2-1, miR-365 and miR-33a on survival in a cohort of early-stage NSCLC patients and in sub-groups of patients classified according to the mutational status of TP53, KRAS, and EGFR. METHODS: mRNA and miRNA expression was determined using TaqMan assays in 110 early-stage NSCLC patients. TP53, KRAS, and EGFR mutations were assessed by Sanger sequencing. RESULTS: NKX2-1 expression was upregulated in never-smokers (P = 0.017), ADK (P < 0.0001) and patients with wild-type TP53 (P = 0.001). A negative correlation between NKX2-1 and miR-365 expression was found (ρ = -0.287; P = 0.003) but there was no correlation between NKX2-1 and miR-33a expression. Overall survival (OS) was longer in patients with high expression of NKX2-1 than in those with low expression (80.8 vs 61.2 months (P = 0.035), while a trend towards longer OS was observed in patients with low miR-365 levels (P = 0.07). The impact of NKX2-1 on OS and DFS was higher in patients with neither TP53 nor KRAS mutations. Higher expression of NKX2-1 was related to higher OS (77.6 vs 54 months; P = 0.017) and DFS (74.6 vs 57.7 months; P = 0.006) compared to low expression. The association between NKX2-1 and OS and DFS was strengthened when the analysis was limited to patients with stage I disease (P = 0.005 and P=0.003 respectively). CONCLUSIONS: NKX2-1 expression impacts prognosis in early-stage NSCLC patients, particularly in those with neither TP53 nor KRAS mutations. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12890-017-0542-z | - |
dc.relation.ispartof | BMC Pulmonary Medicine, 2017, vol. 17, num. 197 | - |
dc.relation.uri | https://doi.org/10.1186/s12890-017-0542-z | - |
dc.rights | cc-by (c) Moisés, Jorge et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.other | Lung cancer | - |
dc.subject.other | Tumor markers | - |
dc.title | NKX2-1 expression as a prognostic marker in early-stage non-small-cell lung cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 674898 | - |
dc.date.updated | 2018-06-12T10:59:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29237428 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
674898.pdf | 695.52 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License