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http://hdl.handle.net/2445/122911
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DC Field | Value | Language |
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dc.contributor.author | Tallini, Luciana R. | - |
dc.contributor.author | Osorio, Edison H. | - |
dc.contributor.author | Dias dos Santos, Vanessa | - |
dc.contributor.author | Souza Borges, Warley de | - |
dc.contributor.author | Kaiser, Marcel | - |
dc.contributor.author | Viladomat Meya, Francesc | - |
dc.contributor.author | Zuanazzi, José Ângelo Silveira | - |
dc.contributor.author | Bastida Armengol, Jaume | - |
dc.date.accessioned | 2018-06-12T14:14:06Z | - |
dc.date.available | 2018-06-12T14:14:06Z | - |
dc.date.issued | 2017-12-09 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122911 | - |
dc.description.abstract | The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/molecules22122191 | - |
dc.relation.ispartof | Molecules, 2017, vol. 22, num. 12, p. 2191 | - |
dc.relation.uri | https://doi.org/10.3390/molecules22122191 | - |
dc.rights | cc-by (c) Tallini, Luciana R. et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Plantes bulboses | - |
dc.subject.classification | Alcaloides | - |
dc.subject.other | Bulb plants | - |
dc.subject.other | Alkaloids | - |
dc.title | Hippeastrum reticulatum (Amaryllidaceae): Alkaloid profiling, biological activities and molecular docking | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 674996 | - |
dc.date.updated | 2018-06-12T14:14:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29232852 | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
Files in This Item:
File | Description | Size | Format | |
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674996.pdf | 2.62 MB | Adobe PDF | View/Open |
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