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DC Field | Value | Language |
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dc.contributor.author | Cillóniz, Catia | - |
dc.contributor.author | Ceccato, Adrian | - |
dc.contributor.author | Calle, Cristina de la | - |
dc.contributor.author | Gabarrús, Albert | - |
dc.contributor.author | Garcia Vidal, Carolina | - |
dc.contributor.author | Almela, M. (Manel) | - |
dc.contributor.author | Soriano Viladomiu, Alex | - |
dc.contributor.author | Martínez, José Antonio | - |
dc.contributor.author | Marco Reverté, Francesc | - |
dc.contributor.author | Vila Estapé, Jordi | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.date.accessioned | 2018-06-15T10:57:54Z | - |
dc.date.available | 2018-06-15T10:57:54Z | - |
dc.date.issued | 2017-08-07 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122992 | - |
dc.description.abstract | Objectives: We aimed to investigate the association between the time to positivity of blood culture (TTP) with clinical outcome and severity of pneumococcal bacteremic pneumonia. Methods: Prospective observational study carried out in 278 hospitalized adult CAP patients with positive blood culture for Streptococcus pneumonia (2003-2015). Results: A total of 278 cases of bacteremic pneumococcal pneumonia were analyzed, median age 62 (46; 79) years. Fifty-one percent of the cases had PSI IV-V. Twenty-one (8%) died within 30-days after admission. The analysis of the TTP showed that the first quartile of the TTP (9.2h) was the best cut-off for differentiating 2 groups of patients at risk, early (TTP <9.2 h) and late (TTP ≥9.2 h) detection groups (AUC 0.66 [95% CI 0.53 to 0.79]). Early TTP was associated with a statistically significant risk of invasive mechanical ventilation (18% vs. 6%, p = 0.007), longer length of hospital stay (12 days vs. 8 days, p<0.001), higher in-hospital mortality (15% vs. 4%, p = 0.010), and 30-day mortality (15% vs. 5%, p = 0.018). After adjustment for potential confounders, regression analyses revealed early TTP as independently associated with high risk of invasive mechanical ventilation (OR 4.60, 95% CI 1.63 to 13.03), longer length of hospital stay (β 5.20, 95% CI 1.81 to 8.52), higher in-hospital mortality (OR 5.35, 95% CI 1.55 to 18.53), and a trend to higher 30-day mortality (OR 2.47, 95% CI 0.85 to 7.21) to be a contributing factor. Conclusion: Our results demonstrate that TTP is an easy to obtain surrogate marker of the severity of pneumococcal pneumonia and a good predictor of its outcome. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0182436 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 8, p. e0182436 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0182436 | - |
dc.rights | cc-by (c) Cillóniz, Catia et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Pneumònia | - |
dc.subject.classification | Pneumococs | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.title | Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 675113 | - |
dc.date.updated | 2018-06-15T10:57:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 2980679 | - |
dc.identifier.pmid | 28787020 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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675113.pdf | 1.77 MB | Adobe PDF | View/Open |
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