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Title: | Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links |
Author: | González Tarragó, Víctor Elosegui Artola, Alberto Bazellières, Elsa Oria, Roger Pérez González, Carlos Roca-Cusachs Soulere, Pere |
Keywords: | Motilitat cel·lular Migració cel·lular Biologia molecular Cell motility Cell migration Molecular biology |
Issue Date: | 1-Mar-2017 |
Publisher: | American Society for Cell Biology |
Abstract: | Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1-fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration. |
Note: | Reproducció del document publicat a: https://doi.org/10.1091/mbc.E17-01-0006 |
It is part of: | Molecular Biology of the Cell, 2017, vol. 28, num. 14, p. 1847-1852 |
URI: | http://hdl.handle.net/2445/123393 |
Related resource: | https://doi.org/10.1091/mbc.E17-01-0006 |
ISSN: | 1059-1524 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Publicacions de projectes de recerca finançats per la UE |
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