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Title: Altered cortical development in fetuses with isolated nonsevere ventriculomegaly assessed by neurosonography
Author: Hahner, Nadine
Puerto Navarro, Bienvenido
Pérez-Cruz, Miriam
Policiano, Catarina
Monterde, Elena
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
Eixarch Roca, Elisenda
Keywords: Diagnòstic prenatal
Ressonància magnètica
Neurobiologia del desenvolupament
Estudi de casos
Prenatal diagnosis
Magnetic resonance
Developmental neurobiology
Case studies
Issue Date: 13-Feb-2018
Publisher: John Wiley & Sons
Abstract: OBJECTIVES: To perform a comprehensive assessment of cortical development in fetuses with isolated nonsevere ventriculomegaly (INSVM) by neurosonography. METHODS: We prospectively included 40 fetuses with INSVM and 40 controls. INSVM was defined as atrial width between 10.0 and 14.9 mm without associated malformation, infection, or chromosomal abnormality. Cortical development was assessed by neurosonography at 26 and 30 weeks of gestation measuring depth of selected sulci and applying a maturation scale from 0 (no appearance) to 5 (maximally developed) of main sulci and areas. RESULTS: INSVM showed underdeveloped calcarine and parieto-occipital sulci. In addition, significant delayed maturation pattern was also observed in regions distant to ventricular system including Insula depth (controls 30.8 mm [SD 1.7] vs INSVM 31.7 mm [1.8]; P = .04), Sylvian fissure grading (>2 at 26 weeks: controls 87.5% vs INSVM 50%, P = .01), mesial area grading (>2 at 30 weeks: controls 95% vs INSVM 62.5%; P = .03), and cingulate sulcus grading (>2 at 30 weeks: controls 100% vs INSVM 80.5%; P = .01). CONCLUSIONS: Fetuses with INSVM showed underdeveloped cortical maturation including also regions, where effect of ventricular dilatation is unlikely. These results suggest that in a proportion of fetuses with INSVM, ventricular dilation might be related with altered cortical architecture.
Note: Versió postprint del document publicat a:
It is part of: Prenatal Diagnosis, 2018, vol. 38, num. 5, p. 365-375
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ISSN: 0197-3851
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)

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