Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/123494
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DC Field | Value | Language |
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dc.contributor.author | Byrne, Annette T. | - |
dc.contributor.author | Alférez, Denis G. | - |
dc.contributor.author | Amant, Frédéric | - |
dc.contributor.author | Annibali, Daniela | - |
dc.contributor.author | Arribas, Joaquín V. (Vicente) | - |
dc.contributor.author | Biankin, Andrew V. | - |
dc.contributor.author | Bruna, Alejandra | - |
dc.contributor.author | Budinská, Eva | - |
dc.contributor.author | Caldas, Carlos | - |
dc.contributor.author | Chang, David K. | - |
dc.contributor.author | Clarke, Robert B. | - |
dc.contributor.author | Clevers, Hans | - |
dc.contributor.author | Coukos, George | - |
dc.contributor.author | Dangles Marie, Virginie | - |
dc.contributor.author | Eckhardt, S. Gail | - |
dc.contributor.author | González Suárez, Eva | - |
dc.contributor.author | Hermans, Els | - |
dc.contributor.author | Hidalgo, Manuel | - |
dc.contributor.author | Jarzabek, Monika A. | - |
dc.contributor.author | Jong, Steven de | - |
dc.contributor.author | Jonkers, Jos | - |
dc.contributor.author | Kemper, Kristel | - |
dc.contributor.author | Lanfrancone, Luisa | - |
dc.contributor.author | Mælandsmo, Gunhild Mari | - |
dc.contributor.author | Marangoni, Elisabetta | - |
dc.contributor.author | Marine, Jean-Christophe | - |
dc.contributor.author | Medico, Enzo | - |
dc.contributor.author | Norum, Jens Henrik | - |
dc.contributor.author | Palmer, Héctor G. | - |
dc.contributor.author | Peeper, Daniel S. | - |
dc.contributor.author | Pelicci, Pier Giuseppe | - |
dc.contributor.author | Piris Gimenez, Alejandro | - |
dc.contributor.author | Roman Roman, Sergio | - |
dc.contributor.author | Rueda, Oscar M. | - |
dc.contributor.author | Seoane Suárez, Joan | - |
dc.contributor.author | Serra Elizalde, Violeta | - |
dc.contributor.author | Soucek, Laura | - |
dc.contributor.author | Vanhecke, Dominique | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.contributor.author | Vinolo, Emilie | - |
dc.contributor.author | Bertotti, Andrea | - |
dc.contributor.author | Trusolino, Livio | - |
dc.date.accessioned | 2018-07-11T14:09:19Z | - |
dc.date.available | 2018-07-11T14:09:19Z | - |
dc.date.issued | 2017-01-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123494 | - |
dc.description.abstract | Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research. | - |
dc.format.extent | 83 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1038/nrc.2016.140 | - |
dc.relation.ispartof | Nature Reviews Cancer, 2017, vol. 17, p. 254–268 | - |
dc.relation.uri | http://dx.doi.org/10.1038/nrc.2016.140 | - |
dc.rights | (c) Macmillan Publishers, 2017 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.other | Cancer | - |
dc.subject.other | Tumor markers | - |
dc.title | Interrogating open issues in cancer precision medicine with patient-derived xenografts | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/682935/EU//PLEIO-RANK | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260791/EU//EUROCANPLATFORM | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/670582/EU//AVATAR | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
dc.identifier.pmid | 28104906 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Byrne_et_al_NRC_2018.pdf | 1.84 MB | Adobe PDF | View/Open |
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