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http://hdl.handle.net/2445/123686
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DC Field | Value | Language |
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dc.contributor.author | García-García, Manuel (Manuel Antonio) | - |
dc.contributor.author | Via i García, Marc | - |
dc.contributor.author | Zarnowiec, Katarzyna | - |
dc.contributor.author | San Miguel Insua, Iria | - |
dc.contributor.author | Escera i Micó, Carles | - |
dc.contributor.author | Clemente, Immaculada | - |
dc.date.accessioned | 2018-07-17T07:25:01Z | - |
dc.date.available | 2018-07-17T07:25:01Z | - |
dc.date.issued | 2017-02-21 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123686 | - |
dc.description.abstract | Attention capture by potentially relevant environmental stimuli is critical for human survival, yet it varies considerably among individuals. A large series of studies has suggested that attention capture may depend on the cognitive balance between maintenance and manipulation of mental representations and the flexible switch between goal-directed representations and potentially relevant stimuli outside the focus of attention; a balance that seems modulated by a prefrontostriatal dopamine pathway. Here, we examined inter-individual differences in the cognitive control of attention through studying the effects of two single nucleotide polymorphisms regulating dopamine at the prefrontal cortex and the striatum (i.e., COMTMet108/158Val and ANKK1/DRD2TaqIA) on stimulus-driven attention capture. Healthy adult participants (N = 40) were assigned to different groups according to the combination of the polymorphisms COMTMet108/158Val and ANKK1/DRD2TaqIA, and were instructed to perform on a well-established distraction protocol. Performance in individuals with a balance between prefrontal dopamine display and striatal receptor density was slowed down by the occurrence of unexpected distracting events, while those with a rather unbalanced dopamine activity were able maintain task performance with no time delay, yet at the expense of a slightly lower accuracy. This advantage, associated to their distinct genetic profiles, was paralleled by an electrophysiological mechanism of phase-resetting of gamma neural oscillation to the novel, distracting events. Taken together, the current results suggest that the epistatic interaction between COMTVal108/158Met and ANKK1/DRD2 TaqIa genetic polymorphisms lies at the basis of stimulus-driven attention capture. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0172362 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 2, p. e0172362 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0172362 | - |
dc.rights | cc-by (c) García-García, Manuel (Manuel Antonio) et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) | - |
dc.subject.classification | Atenció | - |
dc.subject.classification | Dopamina | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.classification | Electroencefalografia | - |
dc.subject.classification | Cognició | - |
dc.subject.other | Attention | - |
dc.subject.other | Dopamine | - |
dc.subject.other | Genetic polymorphisms | - |
dc.subject.other | Electroencephalography | - |
dc.subject.other | Cognition | - |
dc.title | COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668183 | - |
dc.date.updated | 2018-07-17T07:25:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28222164 | - |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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File | Description | Size | Format | |
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668183.pdf | 1.57 MB | Adobe PDF | View/Open |
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