Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/123839
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Domínguez, Francisco | - |
dc.contributor.author | Simón, Carlos | - |
dc.contributor.author | Quiñonero, Alicia | - |
dc.contributor.author | Ramírez, Miguel Ángel | - |
dc.contributor.author | González Muñoz, Elena | - |
dc.contributor.author | Burghardt Coll, Hans | - |
dc.contributor.author | Cervero, Ana | - |
dc.contributor.author | Martínez, Sebastián | - |
dc.contributor.author | Pellicer, Antonio | - |
dc.contributor.author | Palacín Prieto, Manuel | - |
dc.contributor.author | Sánchez-Madrid, Francisco | - |
dc.contributor.author | Yáñez-Mó, María | - |
dc.date.accessioned | 2018-07-24T09:21:42Z | - |
dc.date.available | 2018-07-24T09:21:42Z | - |
dc.date.issued | 2010-10-15 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123839 | - |
dc.description.abstract | Background Understanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic implantation in humans. Methods and Principal Findings Using two human endometrial cell lines characterized by low and high receptivity, we identified the membrane receptor CD98 as a novel molecule selectively and significantly associated with the receptive phenotype. In human endometrial samples, CD98 was the only molecule studied whose expression was restricted to the implantation window in human endometrial tissue. CD98 expression was restricted to the apical surface and included in tetraspanin-enriched microdomains of primary endometrial epithelial cells, as demonstrated by the biochemical association between CD98 and tetraspanin CD9. CD98 expression was induced in vitro by treatment of primary endometrial epithelial cells with human chorionic gonadotropin, 17-β-estradiol, LIF or EGF. Endometrial overexpression of CD98 or tetraspanin CD9 greatly enhanced mouse blastocyst adhesion, while their siRNA-mediated depletion reduced the blastocyst adhesion rate. Conclusions These results indicate that CD98, a component of tetraspanin-enriched microdomains, appears to be an important determinant of human endometrial receptivity during the implantation window. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0013380 | - |
dc.relation.ispartof | PLoS One, 2010, vol. 5, num. 10, p. 1-11 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0013380 | - |
dc.rights | cc-by (c) Domínguez, Francisco et al., 2010 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Implantació de l'ou | - |
dc.subject.classification | Endometri | - |
dc.subject.other | Ovum implantation | - |
dc.subject.other | Endometrium | - |
dc.title | Human endometrial CD98 is essential for blastocyst adhesion | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 660091 | - |
dc.date.updated | 2018-07-24T09:21:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20976164 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
660091.pdf | 4.81 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License