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Title: | Insights into Persistence Mechanisms of a Zoonotic Virus in Bat Colonies Using a Multispecies Metapopulation Model. |
Author: | Pons-Salort, Margarita Serra Cobo, Jordi Jay, Flora López-Roig, Marc Lavenir, Rachel Guillemot, Didier Letort, Véronique Bourhy, Hervé Opatowski, Lulla |
Keywords: | Ratapinyades Virus Colònies animals Bats Viruses Animal colonies |
Issue Date: | 22-Apr-2014 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Rabies is a worldwide zoonosis resulting from Lyssavirus infection. In Europe, Eptesicus serotinus is the most frequently reported bat species infected with Lyssavirus, and thus considered to be the reservoir of European bat Lyssavirus type 1 (EBLV-1). To date, the role of other bat species in EBLV-1 epidemiology and persistence remains unknown. Here, we built an EBLV-1−transmission model based on local observations of a three-cave and four-bat species (Myotis capaccinii, Myotis myotis, Miniopterus schreibersii, Rhinolophus ferrumequinum) system in the Balearic Islands, for which a 1995-2011 serological dataset indicated the continuous presence of EBLV-1. Eptesicus serotinus was never observed in the system during the 16-year follow-up and therefore was not included in the model. We used the model to explore virus persistence mechanisms and to assess the importance of each bat species in the transmission dynamics. We found that EBLV-1 could not be sustained if transmission between M. schreibersii and other bat species was eliminated, suggesting that this species serves as a regional reservoir. Global sensitivity analysis using Sobol's method revealed that following the rate of autumn−winter infectious contacts, M. schreibersii's incubation- and immune-period durations, but not the infectious period length, were the most relevant factors driving virus persistence. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0095610 |
It is part of: | PLoS One, 2014, vol. 9, num. 4, p. 1-11 |
URI: | http://hdl.handle.net/2445/123844 |
Related resource: | https://doi.org/10.1371/journal.pone.0095610 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) Publicacions de projectes de recerca finançats per la UE |
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