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http://hdl.handle.net/2445/123919
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DC Field | Value | Language |
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dc.contributor.author | Taberna, Miren | - |
dc.contributor.author | Mena Cervigón, Marisa | - |
dc.contributor.author | Tous, Sara | - |
dc.contributor.author | Pavón Ribas, Miquel Àngel | - |
dc.contributor.author | Oliva, Marc | - |
dc.contributor.author | León, Xavier | - |
dc.contributor.author | Garcia, Jacinto | - |
dc.contributor.author | Guix, Marta | - |
dc.contributor.author | Hijano, Rafael | - |
dc.contributor.author | Bonfill, Teresa | - |
dc.contributor.author | Aguilà, Anton | - |
dc.contributor.author | Alemany i Vilches, Laia | - |
dc.contributor.author | Mesía Nin, Ricard | - |
dc.date.accessioned | 2018-07-25T08:06:08Z | - |
dc.date.available | 2018-07-25T08:06:08Z | - |
dc.date.issued | 2018-04-17 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123919 | - |
dc.description.abstract | Background Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8 th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Material and methods The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7 th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16(INK4a) or HPV-mRNA), p16(INK4a) positivity alone or the combination of HPV-DNA/p16(INK4a) positivity as diagnostic tests. Results A total of 788 consecutive OPC cases diagnosed from 1991 to 2013 were considered eligible for the analysis. Of these samples, 66 (8.4%) were positive for HPV-DNA and (p16(INK4a) or HPV-mRNA), 83 (10.5%) were p16(INK4a) positive and 58 (7.4%) were double positive for HPV-DNA/p16(INK4a). ICON-S model was the staging system, which performed better in our series when using at least two biomarkers to define HPV-causality. When the same analysis was performed considering only p16(INK4a)-positivity, RPA stage with non-anatomic factors (Princess Margaret) has the best classification based on AIC criteria. Conclusion HPV-relatedness definition for classifying HPV-related OPC patient do impact on TNM classification and patients' survival. Further studies assessing HPV-relatedness definitions are warranted to better classify HPV-related OPC patients in the era of de-escalation clinical trials. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library Science | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194107 | - |
dc.relation.ispartof | Plos One, 2018, Vol. 13, Issue 4: e0194107 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0194107 | - |
dc.rights | cc by (c) Taberna, Miren et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Càncer de coll | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Neck cancer | - |
dc.title | Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T11:44:23Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/603019/EU//COHEAHR | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29664911 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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TabernaM.pdf | 2.32 MB | Adobe PDF | View/Open |
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