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Title: Circulating Metabolites Associated With Alcohol Intake In The European Prospective Investigation Into Cancer And Nutrition Cohort
Author: Van Roekel, Eline H.
Trijsburg, Laura
Assi, Nada
Carayol, Marion
Achaintre, David
Murphy, Neil
Rinaldi, Sabina
Schmidt, Julie A.
Stepien, Magdalena
Kaaks, Rudolf
Kuhn, Tilman
Boeing, Heiner
Iqbal, Khalid
Palli, Domenico
Krogh, Vittorio
Tumino, Rosario
Ricceri, Fulvio
Panico, Salvatore
Peeters, Petra H. M.
Bueno de Mesquita, H. Bas
Ardanaz, Eva
Luján Barroso, Leila
Quirós, J. Ramón
Huerta Castaño, José María
Molina Portillo, Elena
Dorronsoro, Miren
Tsilidis, Konstantinos K.
Riboli, Elio
Rostgaard-Hansen, Agnetha Linn
Tjønneland, Anne
Overvad, Kim
Weiderpass, Elisabete
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Trichopoulou, Antonia
Karakatsani, Anna
Kotanidou, Anastasia
Hakänsson, Anders
Malm, Johan
Weijenberg, Matty P.
Gunter, Marc J.
Jenab, Mazda
Johansson, Mattias
Travis, Ruth C.
Scalbert, Augustin
Ferrari, Pietro
Keywords: Consum d'alcohol
Drinking of alcoholic beverages
Issue Date: 1-May-2018
Publisher: Mdpi
Abstract: Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
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It is part of: Nutrients, 2018-05-01, Vol. 10: 654
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Publicacions de projectes de recerca finançats per la UE

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