Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/123990
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hernández, Gonzalo | - |
dc.contributor.author | Ramírez, María José | - |
dc.contributor.author | Minguillón, Jordi | - |
dc.contributor.author | Quiles, Paco | - |
dc.contributor.author | Ruiz de Garibay, Gorka | - |
dc.contributor.author | Aza-Carmona, Miriam | - |
dc.contributor.author | Bogliolo, Massimo | - |
dc.contributor.author | Pujol, Roser | - |
dc.contributor.author | Prados-Carvajal, Rosario | - |
dc.contributor.author | Fernandez, Juana | - |
dc.contributor.author | Garcia, Nadia | - |
dc.contributor.author | López, Adriá | - |
dc.contributor.author | Gutiérrez Enríquez, Sara | - |
dc.contributor.author | Díez Gibert, Orland | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Salinas Masdeu, Mònica | - |
dc.contributor.author | Teulé-Vega, Àlex | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Peterlongo, Paolo | - |
dc.contributor.author | Schindler, Detlev | - |
dc.contributor.author | Huertas, Pablo | - |
dc.contributor.author | Puente, Xose S. | - |
dc.contributor.author | Lázaro García, Conxi | - |
dc.contributor.author | Pujana Genestar, M. Ángel | - |
dc.contributor.author | Surrallés, Jordi | - |
dc.date.accessioned | 2018-07-27T09:00:54Z | - |
dc.date.available | 2018-07-27T09:00:54Z | - |
dc.date.issued | 2018-03-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123990 | - |
dc.description.abstract | BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer development and therapeutic vulnerabilities. Here, we identify EDC4, a known component of processing-bodies and regulator of mRNA decapping, as a member of the BRCA1-BRIP1-TOPBP1 complex. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. EDC4 deficiency leads to genome instability and hypersensitivity to DNA interstrand cross-linking drugs and PARP inhibitors. Lack-of-function mutations in EDC4 were detected in BRCA1/2-mutation-negative breast cancer cases, suggesting a role in breast cancer susceptibility. Collectively, this study recognizes EDC4 with a dual role in decapping and DNA repair whose inactivation phenocopies BRCA1 deficiency. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-03433-3 | - |
dc.relation.ispartof | Nature Communications, 2018-03-06, Vol. 9 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-018-03433-3 | - |
dc.rights | cc-by (c) Hernández, Gonzalo et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Reparació de l'ADN | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Gens | - |
dc.subject.other | DNA repair | - |
dc.subject.other | Cancer | - |
dc.subject.other | Genes | - |
dc.title | Decapping Protein Edc4 Regulates Dna Repair And Phenocopies Brca1 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T11:47:02Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/665919/EU//P-SPHERE | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/305421/EU//EUROFANCOLEN | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29511213 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
HernandezG.pdf | 1.89 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License