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Title: | Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36 |
Author: | Cortese, Rene Gileles-Hillel, Alex Khalyfa, Abdelnaby Almendros López, Isaac Akbarpour, Mahzad Khalyfa, Ahamed A. Qiao, Zhuanhong Garcia, Tzintzuni Andrade, Jorge Gozal, David |
Keywords: | Síndromes d'apnea del son Oxigen en l'organisme Obesitat Inflamació Morbiditat Malalties cardiovasculars Sleep apnea syndromes Oxygen in the body Obesity Inflammation Morbidity Cardiovascular diseases |
Issue Date: | 27-Feb-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with cardiovascular morbidities. In CIH-exposed mice, closely mimicking the chronicity of human OSA, increased accumulation and proliferation of pro-inflammatory metabolic M1-like macrophages highly expressing CD36, emerged in aorta. Transcriptomic and MeDIP-seq approaches identified activation of pro-atherogenic pathways involving a complex interplay of histone modifications in functionally-relevant biological pathways, such as inflammation and oxidative stress in aorta macrophages. Discontinuation of CIH did not elicit significant improvements in aorta wall macrophage phenotype. However, CIH-induced aorta changes were absent in CD36 knockout mice, Our results provide mechanistic insights showing that CIH exposures during sleep in absence of concurrent pro-atherogenic settings (i.e., genetic propensity or dietary manipulation) lead to the recruitment of CD36(+)high macrophages to the aortic wall and trigger atherogenesis. Furthermore, long-term CIH-induced changes may not be reversible with usual OSA treatment. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep43648 |
It is part of: | Scientific Reports, 2017, vol. 7, p. 43648 |
URI: | http://hdl.handle.net/2445/124205 |
Related resource: | https://doi.org/10.1038/srep43648 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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