Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124207
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dc.contributor.authorLéveillé, Nicolas-
dc.contributor.authorElkon, Ran-
dc.contributor.authorDavalos, Veronica-
dc.contributor.authorManoharan, Vijayalaxmi-
dc.contributor.authorHollingworth, Dave-
dc.contributor.authorVrielink, Joachim Oude-
dc.contributor.authorLe Sage, Carlos-
dc.contributor.authorMelo, Carlos A.-
dc.contributor.authorHorlings, Hugo M.-
dc.contributor.authorWesseling, Jelle-
dc.contributor.authorUle, Jernej-
dc.contributor.authorEsteller, Manel-
dc.contributor.authorRamos, Andres-
dc.contributor.authorAgami, Reuven-
dc.date.accessioned2018-09-03T11:00:57Z-
dc.date.available2018-09-03T11:00:57Z-
dc.date.issued2011-10-25-
dc.identifier.urihttps://hdl.handle.net/2445/124207-
dc.description.abstractMicroRNAs (miRNAs) interact with 3'-untranslated regions of messenger RNAs to restrict expression of most protein-coding genes during normal development and cancer. RNA-binding proteins (RBPs) can control the biogenesis, stability and activity of miRNAs. Here we identify RBM38 in a genetic screen for RBPs whose expression controls miRNA access to target mRNAs. RBM38 is induced by p53 and its ability to modulate miRNA-mediated repression is required for proper p53 function. In contrast, RBM38 shows lower propensity to block the action of the p53-controlled miR-34a on SIRT1. Target selectivity is determined by the interaction of RBM38 with uridine-rich regions near miRNA target sequences. Furthermore, in large cohorts of human breast cancer, reduced RBM38 expression by promoter hypermethylation correlates with wild-type p53 status. Thus, our results indicate a novel layer of p53 gene regulation, which is required for its tumour suppressive function.-
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1038/ncomms1519-
dc.relation.ispartofNature Communications, 2011, vol. 2, num. 513-
dc.relation.urihttp://dx.doi.org/10.1038/ncomms1519-
dc.rightscc by-nc-nd (c) Léveillé et al., 2011-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/-
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))-
dc.subject.classificationRNA-
dc.subject.classificationCàncer de mama-
dc.subject.otherRNA-
dc.subject.otherBreast cancer-
dc.titleSelective inhibition of microRNA accessibility by RBM38 is required for p53 activity-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2018-07-24T12:59:16Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/201900/EU//MIREG-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid22027593-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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