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https://hdl.handle.net/2445/124207
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DC Field | Value | Language |
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dc.contributor.author | Léveillé, Nicolas | - |
dc.contributor.author | Elkon, Ran | - |
dc.contributor.author | Davalos, Veronica | - |
dc.contributor.author | Manoharan, Vijayalaxmi | - |
dc.contributor.author | Hollingworth, Dave | - |
dc.contributor.author | Vrielink, Joachim Oude | - |
dc.contributor.author | Le Sage, Carlos | - |
dc.contributor.author | Melo, Carlos A. | - |
dc.contributor.author | Horlings, Hugo M. | - |
dc.contributor.author | Wesseling, Jelle | - |
dc.contributor.author | Ule, Jernej | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Ramos, Andres | - |
dc.contributor.author | Agami, Reuven | - |
dc.date.accessioned | 2018-09-03T11:00:57Z | - |
dc.date.available | 2018-09-03T11:00:57Z | - |
dc.date.issued | 2011-10-25 | - |
dc.identifier.uri | https://hdl.handle.net/2445/124207 | - |
dc.description.abstract | MicroRNAs (miRNAs) interact with 3'-untranslated regions of messenger RNAs to restrict expression of most protein-coding genes during normal development and cancer. RNA-binding proteins (RBPs) can control the biogenesis, stability and activity of miRNAs. Here we identify RBM38 in a genetic screen for RBPs whose expression controls miRNA access to target mRNAs. RBM38 is induced by p53 and its ability to modulate miRNA-mediated repression is required for proper p53 function. In contrast, RBM38 shows lower propensity to block the action of the p53-controlled miR-34a on SIRT1. Target selectivity is determined by the interaction of RBM38 with uridine-rich regions near miRNA target sequences. Furthermore, in large cohorts of human breast cancer, reduced RBM38 expression by promoter hypermethylation correlates with wild-type p53 status. Thus, our results indicate a novel layer of p53 gene regulation, which is required for its tumour suppressive function. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms1519 | - |
dc.relation.ispartof | Nature Communications, 2011, vol. 2, num. 513 | - |
dc.relation.uri | http://dx.doi.org/10.1038/ncomms1519 | - |
dc.rights | cc by-nc-nd (c) Léveillé et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | RNA | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.other | RNA | - |
dc.subject.other | Breast cancer | - |
dc.title | Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:59:16Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/201900/EU//MIREG | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22027593 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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LeveilleN.pdf | 2.56 MB | Adobe PDF | View/Open |
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