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Title: | Revealed versus concealed criteria for placental insufficiency in an unselected obstetric population in late pregnancy (RATIO37): randomised controlled trial study protocol. |
Author: | Figueras Retuerta, Francesc Gratacós Solsona, Eduard Rial, Marta Gull, Ilan Krofta, Ladislav Lubusky, Marek Cruz-Martínez, Rogelio Cruz Lemini, Mónica Cristina Martinez-Rodriguez, Miguel Socias, Pamela Aleuanlli, Cristina Parra Cordero, Mauro |
Keywords: | Diagnòstic prenatal Complicacions en l'embaràs Retard del creixement intrauterí Ecografia Doppler Espanya Xile Mèxic Txèquia Israel Prenatal diagnosis Complications of pregnancy Fetal growth retardation Doppler ultrasonography Spain Chile Mexico Czech Republic Israel |
Issue Date: | 15-Jun-2017 |
Publisher: | BMJ Publishing Group |
Abstract: | INTRODUCTION: Fetal growth restriction (FGR) affects 5%-10% of all pregnancies, contributing to 30%-50% of stillbirths. Unfortunately, growth restriction often is not detected antenatally. The last weeks of pregnancy are critical for preventing stillbirth among babies with FGR because there is a pronounced increase in stillbirths among growth-restricted fetuses after 37 weeks of pregnancy. Here we present a protocol (V.1, 23 May 2016) for the RATIO37 trial, which evaluates an integrated strategy for accurately selecting at-risk fetuses for delivery at term. The protocol is based on the combination of fetal biometry and cerebroplacental ratio (CPR). The primary objective is to reduce stillbirth rates. The secondary aims are to detect low birth weights and adverse perinatal outcomes. METHODS AND ANALYSIS: The study is designed as multicentre (Spain, Chile, Mexico,Czech Republic and Israel), open-label, randomised trial with parallel groups. Singleton pregnancies will be invited to participate after routine second-trimester ultrasound scan (19+0-22+6 weeks of gestation), and participants will be randomly allocated to receive revealed or concealed CPR evaluation. Then, a routine ultrasound and Doppler scan will be performed at 36+0-37+6 weeks. Sociodemographic and clinical data will be collected at enrolment. Ultrasound and Doppler variables will be recorded at 36+0-37+6 weeks of pregnancy. Perinatal outcomes will be recorded after delivery. Univariate (with estimated effect size and its 95% CI) and multivariate (mixed-effects logistic regression) comparisons between groups will be performed. ETHICS AND DISSEMINATION: The study will be conducted in accordance with the principles of Good Clinical Practice. This study was accepted by the Clinical Research Ethics Committee of Hospital Clinic Barcelona on 23May 2016. Subsequent approval by individual ethical committees and competent authorities was granted. The study results will be published in peer-reviewed journals and disseminated at international conferences. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/bmjopen-2016-014835 |
It is part of: | BMJ Open, 2017, vol. 7, num. 6, p. e014835 |
URI: | http://hdl.handle.net/2445/124257 |
Related resource: | https://doi.org/10.1136/bmjopen-2016-014835 |
ISSN: | 2044-6055 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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