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http://hdl.handle.net/2445/124263
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DC Field | Value | Language |
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dc.contributor.author | Rosso, Marina | - |
dc.contributor.author | Majem, Blanca | - |
dc.contributor.author | Devis, Laura | - |
dc.contributor.author | Lapyckyj, Lara | - |
dc.contributor.author | Besso, María José | - |
dc.contributor.author | Llauradó, Marta | - |
dc.contributor.author | Abascal, María Florencia | - |
dc.contributor.author | Matos, María Laura | - |
dc.contributor.author | Lanau, Lucia | - |
dc.contributor.author | Castellví, Josep | - |
dc.contributor.author | Sánchez, José Luis | - |
dc.contributor.author | Pérez Benavente, Asunción | - |
dc.contributor.author | Gil Moreno, Antonio | - |
dc.contributor.author | Reventós Puigjaner, Jaume | - |
dc.contributor.author | Santamaria Margalef, Anna | - |
dc.contributor.author | Rigau, Marina | - |
dc.contributor.author | Hebe Vazquez Levin, Mónica | - |
dc.date.accessioned | 2018-09-04T13:59:36Z | - |
dc.date.available | 2018-09-04T13:59:36Z | - |
dc.date.issued | 2017-09-21 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124263 | - |
dc.description.abstract | Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern. Epithelial-to-mesenchymal transition (EMT) has been reported in OC and downregulation of Epithelial cadherin (E-cadherin) is a hallmark of this process. However, findings on the relationship between E-cadherin levels and OC progression, dissemination and aggressiveness are controversial. In this study, the evaluation of E-cadherin expression in an OC tissue microarray revealed its prognostic value to discriminate between advanced-and early-stage tumors, as well as serous tumors from other histologies. Moreover, E-cadherin, Neural cadherin (N-cadherin), cytokeratins and vimentin expression was assessed in TOV-112, SKOV-3, OAW-42 and OV-90 OC cell lines grown in monolayers and under anchorage-independent conditions to mimic ovarian tumor cell dissemination, and results were associated with cell aggressiveness. According to these EMT-related markers, cell lines were classified as mesenchymal (M; TOV-112), intermediate mesenchymal (IM; SKOV-3), intermediate epithelial (IE; OAW-42) and epithelial (E; OV-90). M-and IM-cells depicted the highest migration capacity when grown in monolayers, and aggregates derived from M-and IM-cell lines showed lower cell death, higher adhesion to extracellular matrices and higher invasion capacity than E- antigen 125 levels more than 500 U/mL and platinum-free intervals less than 6 months. Altogether, E-cadherin expression levels were found relevant for the assessment of OC progression and aggressiveness.and IE-aggregates. The analysis of E-cadherin, N-cadherin, cytokeratin 19 and vimentin mRNA levels in 20 advanced-stage high-grade serous human OC ascites showed an IM phenotype in all cases, characterized by higher proportions of N-to E-cadherin and vimentin to cytokeratin 19. In particular, higher E-cadherin mRNA levels were associated with cancer antigen 125 levels more than 500 U/mL and platinum-free intervals less than 6 months. Altogether, E-cadherin expression levels were found relevant for the assessment of OC progression and aggressiveness. | - |
dc.format.extent | 25 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0184439 | - |
dc.relation.ispartof | PLos One, 2017, vol. 12, num. 9, p. e0184439 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0184439 | - |
dc.rights | cc by (c) Rosso et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer d'ovari | - |
dc.subject.classification | Ascites | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Ovarian cancer | - |
dc.subject.other | Gene expression | - |
dc.title | E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:00:59Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/269285/EU//PROTBIOFLUID | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28934230 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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RossoM.pdf | 10.17 MB | Adobe PDF | View/Open |
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