Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124271
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sarink, Danja | - |
dc.contributor.author | Schock, Helena | - |
dc.contributor.author | Johnson, Theron | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Holm, Marianne | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | His, Mathilde | - |
dc.contributor.author | Kvaskoff, Marina | - |
dc.contributor.author | Boeing, Heiner | - |
dc.contributor.author | Lagiou, Pagona | - |
dc.contributor.author | Papatesta, Eleni Maria | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Pala, Valeria | - |
dc.contributor.author | Mattiello, Amalia | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Sacerdote, Carlotta | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | van Gils, Carla H. | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Agudo, Antonio | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Ardanaz, Eva | - |
dc.contributor.author | Amiano, Pilar | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Travis, Ruth C. | - |
dc.contributor.author | Dossus, Laure | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Rinaldi, Sabina | - |
dc.contributor.author | Merritt, Melissa A. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Fortner, Renée T. | - |
dc.date.accessioned | 2018-09-05T06:59:59Z | - |
dc.date.available | 2018-09-05T06:59:59Z | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124271 | - |
dc.description.abstract | Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has not previously been investigated. A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. This study included 1,976 incident invasive breast cancer cases [estrogen receptor positive (ER+), n = 1,598], matched 1: 1 to controls. Women were pre- or postmenopausal at blood collection. Serum sRANKL was quantified using an ELISA, serum OPG using an electrochemiluminescent assay. Risk ratios (RR) and 95% confidence intervals (95% CI) were calculated using conditional logistic regression. Associations between sRANKL and breast cancer risk differed by tumor hormone receptor status (P-het = 0.05). Higher concentrations of sRANKL were positively associated with risk of ER+ breast cancer [5th vs. 1st quintile RR 1.28 (95% CI, 1.01-1.63); P-trend = 0.20], but not ER+ disease. For both ER+ and estrogen and progesterone receptor positive (ER+PR+) breast cancer, results considering the sRANKL/OPG ratio were similar to those for sRANKL; we observed a suggestive inverse association between the ratio and ER+PR+ disease [5th vs. 1st quintile RR = 0.60 (0.31-1.14); P-trend = 0.03]. This study provides the first large-scale prospective data on circulating sRANKL and breast cancer. We observed limited evidence for an association between sRANKL and breast cancer risk. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for Cancer Research | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1158/1940-6207.CAPR-17-0125 | - |
dc.relation.ispartof | Cancer Prevention Research, 2017, vol. 10, num. 9, p. 525-534 | - |
dc.relation.uri | https://doi.org/10.1158/1940-6207.CAPR-17-0125 | - |
dc.rights | (c) American Association for Cancer Research, 2017 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Receptors d'hormones | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Hormone receptors | - |
dc.title | Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:01:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28701332 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
SarinkD.pdf | 356.98 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.