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http://hdl.handle.net/2445/124281
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DC Field | Value | Language |
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dc.contributor.author | Muñoz Soriano, Verónica | - |
dc.contributor.author | Domingo Muelas, Ana | - |
dc.contributor.author | Li, Tianlu | - |
dc.contributor.author | Gamero, Esther | - |
dc.contributor.author | Bizy, Alexandra | - |
dc.contributor.author | Fariñas, Isabel | - |
dc.contributor.author | Alepuz, Paula | - |
dc.contributor.author | Paricio, Nuria | - |
dc.date.accessioned | 2018-09-05T08:00:31Z | - |
dc.date.available | 2018-09-05T08:00:31Z | - |
dc.date.issued | 2017-08-29 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124281 | - |
dc.description.abstract | Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin involved in actin dynamics during DC, is regulated by and mediates eIF5A effects. Finally, eIF5A controls cell migration and regulates Diaphanous levels also in mammalian cells. Our results uncover an evolutionary conserved role of eIF5A regulating cytoskeleton-dependent processes through translation of formins in eukaryotes. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-10057-y | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-017-10057-y | - |
dc.rights | cc by (c) Muñoz Soriano et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Cèl·lules eucariotes | - |
dc.subject.classification | Citosquelet | - |
dc.subject.other | Eukaryotic cells | - |
dc.subject.other | Cytoskeleton | - |
dc.title | Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:02:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28852021 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Munoz-SorianoV.pdf | 3.24 MB | Adobe PDF | View/Open |
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