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Title: | Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study |
Author: | Pérez Cornago, Aurora Appleby, Paul N. Pischon, Tobias Tsilidis, Konstantinos K. Tjønneland, Anne Olsen, Anja Overvad, Kim Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Steffen, Annika Trichopoulou, Antonia Lagiou, Pagona Kritikou, Maria Krogh, Vittorio Palli, Domenico Sacerdote, Carlotta Tumino, Rosario Bueno de Mesquita, H. Bas Agudo, Antonio Larrañaga, Nerea Molina Portillo, Elena Barricarte, Aurelio Chirlaque, María Dolores Quirós, J. Ramón Stattin, Pär Häggström, Christel Wareham, Nicholas J. Khaw, Kay-Tee Schmidt, Julie A. Gunter, Marc J. Freisling, Heinz Aune, Dagfinn Ward, Heather A. Riboli, Elio Key, Timothy J. Travis, Ruth C. |
Keywords: | Obesitat Càncer de pròstata Obesity Prostate cancer |
Issue Date: | 13-Jul-2017 |
Publisher: | BioMed Central |
Abstract: | Background: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average of 13.9 years of follow-up, there were 7024 incident prostate cancers and 934 prostate cancer deaths. Results: Height was not associated with total prostate cancer risk. Subgroup analyses showed heterogeneity in the association with height by tumour grade (P-heterogeneity = 0.002), with a positive association with risk for high-grade but not low-intermediate-grade disease (HR for high-grade disease tallest versus shortest fifth of height, 1.54; 95% CI, 1.18-2.03). Greater height was also associated with a higher risk for prostate cancer death (HR = 1.43, 1.14-1.80). Body mass index (BMI) was significantly inversely associated with total prostate cancer, but there was evidence of heterogeneity by tumour grade (P-heterogeneity = 0.01; HR = 0.89, 0.79-0.99 for low-intermediate grade and HR = 1.32, 1.01-1.72 for high-grade prostate cancer) and stage (P-heterogeneity = 0.01; HR = 0.86, 0.75-0.99 for localised stage and HR = 1.11, 0.92-1.33 for advanced stage). BMI was positively associated with prostate cancer death (HR = 1.35, 1.09-1.68). The results for waist circumference were generally similar to those for BMI, but the associations were slightly stronger for high-grade (HR = 1.43, 1.07-1.92) and fatal prostate cancer (HR = 1.55, 1.23-1.96). Conclusions: The findings from this large prospective study show that men who are taller and who have greater adiposity have an elevated risk of high-grade prostate cancer and prostate cancer death. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12916-017-0876-7 |
It is part of: | BMC Medicine, 2017, vol. 15, num. 115 |
URI: | http://hdl.handle.net/2445/124347 |
Related resource: | https://doi.org/10.1186/s12916-017-0876-7 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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