Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124402
Title: Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Author: Phelan, Catherine M.
Kuchenbaecker, Karoline B.
Tyrer, Jonathan P.
Kar, Siddhartha P.
Lawrenson, Kate
Winham, Stacey J.
Dennis, Joe
Pirie, Ailith
Riggan, Marjorie
Chornokur, Ganna
Earp, Madalene A.
Hazelett, Dennis
Ottini, Laura
Wilkens, Lynne R.
Arun, Banu K.
Lester, Jenny
Peixoto, Ana
Dicks, Ed
Rookus, Matti A.
Rhiem, Kerstin
Harrington, Patricia A.
Tinker, Anna V.
Ganz, Patricia A.
Berchuck, Andrew
Holland, Helene
Thompson, Pamela J.
Aloisio, Aimee A. D’
Brooks-Wilson, Angela R.
Nussbaum, Robert L.
Moysich, Kirsten B.
James, Paul
Bernardini, Marcus Q.
Tan, Yen Y.
Schmutzler, Rita Katharina
Imyanitov, Evgeny N.
Cannioto, Rikki
Pfeiler, Georg
Orr, Nicholas
Jakubowska, Anna
Senter, Leigha
Beckmann, Matthias W.
John, Esther M.
Conner, Thomas
Singer, Christian F.
McLaughlin, John R.
Leroux, Dominique
Kannisto, Päivi
Easton, Douglas F.
Ekici, Arif B.
Larrañaga, Nerea
Leminen, Arto
Aben, Katja K.
Fountzilas, George
Yang, Hannah
Moffitt, Melissa
Rantala, Johanna
Sieh, Weiva
Trichopoulou, Antonia
Pelttari, Liisa M.
Sobol, Hagay
Tone, Alicia
Evans, D. Gareth
Beeghly-Fadiel, Alicia
McAlpine, Jessica N.
Aravantinos, Gerasimos
Gehrig, Andrea
Massuger, Leon F. A. G.
Rossing, Mary Anne
Adams, Marcia
Poblete, Samantha R.
Banerjee, Susana N.
Cunningham, Julie M.
Glendon, Gord
Chen, Xiao Qing
Defazio, Anna
Buys, Saundra S.
Rodriguez Antona, Cristina
Goranova, Teodora
Gronwald, Jacek
Dorfling, Cecilia M.
Severi, Gianluca
Amos, Christopher I.
Travis, Ruth C.
Mendoza-Fandino, Gustavo A.
Vierkant, Robert A.
Eccles, Diana
van den Berg, David Berg, David
Damirovna, Sakaeva Dina
Varon-Mateeva, Raymonda
Goodman, Marc T.
Barkardottir, Rosa B.
Kopperud, Reidun K.
Runnebaum, Ingo B.
Le, Nhu D.
Chiquette, Jocelyne
Johnatty, Sharon
Olswold, Curtis
Woo, Michelle
Mensenkamp, Arjen R.
Greene, Mark H.
Wu, Anna H.
Cook, Jackie
Ana, Vega
Fogarty, Zachary C.
Pike, Malcolm C.
Teixeira, Manuel R.
Eeles, Rosalind A.
Gentry-Maharaj, Aleksandra
van Nieuwenhuysen, Els
Mazoyer, Sylvie
Lele, Shashikant B.
Delnatte, Capucine
Milne, Roger L.
Thomassen, Mads
Hunter, David J.
Gruber, Stephen B.
Arver, Brita
Schoemaker, Minouk J.
Nevanlinna, Heli
Vergote, Ignace
Caligo, Maria A.
Musinsky, Jacob
Hauke, Jan
Thull, Darcy L.
Ejlertsen, Bent
Adlard, Julian
Wappenschmidt, Barbara
Friedman, Eitan
Davidson, Rosemarie
Doherty, Jennifer A.
Arnold, Norbert
Piedmonte, Marion
O'Malley, David M.
Chung, Wendy K.
Barrowdale, Daniel
Pejovic, Tanja
Antonenkova, Natalia N.
Elvira, Mingajeva
Garcia Barberan, Vanesa
Chang-Claude, Jenny
van der Luijt, Rob B.
Wijnen, Juul
Sellers, Thomas A.
Balmaña, Judith
Wolk, Alicja
Chenevix-Trench, Georgia
Kobel, Martin
Frost, Debra
Rice, Patricia
Ferrer, Sandra Fert
Rappaport-Fuerhauser, Christine
Vijai, Joseph
Eng, Kevin H.
Toland, Amanda Ewart
Foulkes, William D.
Hung, Jillian
Lilyquist, Jenna
Høgdall, Claus K.
Izatt, Louise
Hansen, Thomas V. O.
Lu, Karen H.
Luccarini, Craig
Lee, Andrew
Weinberg, Clarice R.
Claes, Kathleen B. M.
Benitez, Javier
Radice, Paolo
Borg, Åke
Karlan, Beth Y.
Bermisheva, Marina
Bodelon, Clara
Cramer, Daniel W.
Fridley, Brooke L.
Pearce, Celeste L.
Walker, Lisa
Peterlongo, Paolo
Soucy, Penny
Olsson, Håkan
Spurdle, Amanda B.
Carney, Michael E.
Aalfs, Cora M.
Chan, Salina B.
Huang, Ruea-Yea
Bogdanova, Natalia V.
Laitman, Yael
Tischkowitz, Marc
Kelemen, Linda E.
Kast, Karin
Lesueur, Fabienne
Black, Amanda
Phillips, Kelly-Anne
Izquierdo i Font, Àngel Xavier
Yannoukakos, Drakoulis
Damiola, Francesca
Montagna, Marco
Lundvall, Lene
Lee, Janet M.
Wang-Gohrke, Shan
Side, Lucy E.
Bonanni, Bernardo
Setiawan, V. Wendy
McGuire, Valerie
Simard, Jacques
Khusnutdinova, Elza
Engel, Christoph
Bruinsma, Fiona
Marchand, Loïc Le
Iversen, Edwin S.
Jernetz, Mats
Flanagan, James M.
Stadler, Zsofia
Hogervorst, Frans B. L.
Ramus, Susan J.
Teo, Soo-Hwang
Ferguson, Sarah
Kiiski, Johanna I.
Leslie, Goska
Hillemanns, Peter
Birrer, Michael J.
Huntsman, David G.
Fostira, Florentia
Sucheston-Campbell, Lara E.
Moes-Sosnowska, Joanna
Paul, James
Domchek, Susan M.
van ensburg, Elizabeth J.
Kupryjanczyk, Jolanta
Heetvelde, Mattias Van
Bradbury, Angela R.
Kim, Sung-Won
Díez Gibert, Orland
Azzollini, Jacopo
Poppe, Bruce
Menon, Usha
Ness, Roberta B.
May, Taymaa
Prokofyeva, Darya
Pugh, Elizabeth
Eilber, Ursula
Buecher, Bruno
Ding, Yuan Chun
van der Hout, Annemarie H.
Goldgar, David E.
Ong, Kai Ren
Dork, Thilo
Giles, Graham G.
Hulick, Peter J.
Lázaro García, Conxi
Szafron, Lukasz
Brewer, Carole
Edwards, Todd L.
Southey, Melissa C.
Pedersen, Inge Søkilde
Hein, Alexander
Ellis, Steve
Hildebrandt, Mat
Study EMBRACE
Glasspool, Rosalind
Peissel, Bernard
Monteiro, Alvaro N.
Onland-Moret, N. Charlotte
Piskorz, Anna M.
Huzarski, Tomasz
Tihomirova, Laima
Neuhausen, Susan L.
Chanock, Stephen J.
Rothstein, Joseph H.
Sandler, Dale P.
Pujana Genestar, M. Ángel
Dao, Fanny
Bean, Yukie
Godwin, Andrew K.
Webb, Penelope M.
Richardson, Andrea
Dansonka-Mieszkowska, Agnieszka
Orsulic, Sandra
Kjaer, Susanne Krüger
Hahnen, Eric
Pezzani, Lidia
Nedergaard, Lotte
Kwong, Ava
Hooning, Maartje J.
Merritt, Melissa A.
Cook, Linda S.
Risch, Harvey A.
Kruse, Torben A.
Palli, Domenico
Lyra, Paulo C.
Meijers-Heijboer, Hanne
Coetzee, Simon
Lambrechts, Diether
Zorn, Kristin K.
Salvesen, Helga B.
Szabo, Csilla I.
Jensen, Allan
Blankstein, Kenneth
Lee, Jong Won
Bjorge, Line
Beesley, Jonathan
Papi, Laura
Fortner, Renée T.
Trabert, Britton
Romm, Jane
Shelford, Tameka
Rennert, Gad
Tung, Nadine
Tworoger, Shelley S.
Kennedy, Catherine J.
Håkansson, Niclas
Janavicius, Ramunas
Lissowska, Jolanta
Steinemann, Doris
Jensen, Uffe Birk
Liang, Dong
Karnezis, Anthony N.
Permuth, Jennifer B.
Campbell, Ian
Gore, Martin
Doheny, Kimberly F.
Wu, Xifeng
Butzow, Ralf
Kiemeney, Lambertus A. L. M.
McNeish, Iain
Gerdes, Anne-Marie
Liebrich, Clemens
Tea, Muy-Kheng
Edwards, Digna Velez
Stoppa-Lyonnet, Dominique
Tognazzo, Silvia
Mulligan, Anna Marie
Siddiqui, Nadeem
Hodgson, Shirley
Vratimos, Athanassios
Wand, Dorothea
van Altena, Anne M.
Isaacs, Claudine
Park-Simon, Tjoung-Won
Lipworth, Loren
Brunet, Joan
Vanderstichele, Adriaan
Sukiennicki, Grzegorz
Caldes, Trinidad
Mai, Phuong L.
Thomsen, Liv Cecilie Vestrheim
Sharma, Priyanka
Peeters, Petra H. M.
Mitchell, Gillian
Anton-Culver, Hoda
Hosking, Karen
Daly, Mary B.
Sutphen, Rebecca
Dossus, Laure
Rodriguez, Gustavo C.
Durst, Matthias
Olopade, Olufunmilayo I.
Chiew, Yoke-Eng
Walsh, Christine
Schildkraut, Joellen M.
Odunsi, Kunle
Henderson, Alex
Garcia, Maria Jose
Dworniczak, Bernd
Sutter, Christian
Lecarpentier, Julie
Goode, Ellen L.
Garber, Judy
Wentzensen, Nicolas
Barjhoux, Laure
Gayther, Simon A.
Antoniou, Antonis C.
Manoukian, Siranoush
Niederacher, Dieter
Prieur, Fabienne
Larson, Melissa C.
Olah, Edith
Pocza, Timea
Andrulis, Irene L.
Terry, Kathryn L.
Harris, Holly R.
Lubinski, Jan
Cescon, Terence
Hamann, Ute
Osorio, Ana
Robson, Mark
Levine, Douglas A.
Poole, Elizabeth M.
Park, Sue K.
Bojesen, Anders
Ziogas, Argyrios
Couch, Fergus J.
Whittemore, Alice
Meindl, Alfons
Brenton, James D.
Broberg, Per
Pharoah, Paul D. P.
Nathanson, Katherine L.
Swerdlow, Anthony J.
Porteous, Mary E.
Haiman, Christopher A.
Blok, Marinus J.
McGuffog, Lesley
Pujol, Pascal
Offit, Kenneth
Weitzel, Jeffrey N.
Taylor, Jack A.
Rudolph, Anja
Fasching, Peter A.
Modugno, Francesmary
Friebel, Tara M.
Narod, Steven A.
Durán, Mercedes
Jones, Michael E.
Song, Honglin
Høgdall, Estrid
Brinton, Louise A.
Keywords: Càncer d'ovari
Ovarian cancer
Issue Date: 1-May-2017
Publisher: Nature Publishing
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826
It is part of: Nature Genetics, 2017, vol. 49, num. 5, p. 680-691
URI: http://hdl.handle.net/2445/124402
Related resource: https://doi.org/10.1038/ng.3826
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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