Title: | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer |
Author: | Phelan, Catherine M. Kuchenbaecker, Karoline B. Tyrer, Jonathan P. Kar, Siddhartha P. Lawrenson, Kate Winham, Stacey J. Dennis, Joe Pirie, Ailith Riggan, Marjorie J. Chornokur, Ganna Earp, Madalene A. Chan, Salina B. Huang, Ruea-Yea Bogdanova, Natalia V. Laitman, Yael Tischkowitz, Marc Kelemen, Linda E. Kast, Karin Lesueur, Fabienne Black, Amanda Rhiem, Kerstin Wu, Anna H. Phillips, Kelly-Anne Izquierdo i Font, Àngel Xavier Yannoukakos, Drakoulis Damiola, Francesca Montagna, Marco Lundvall, Lene Lee, Janet M. Wang-Gohrke, Shan Side, Lucy E. Bonanni, Bernardo Cook, Jackie Harrington, Patricia A. Setiawan, V. Wendy McGuire, Valerie Simard, Jacques Khusnutdinova, Elza Engel, Christoph Bruinsma, Fiona Marchand, Loïc Le Iversen, Edwin S. Jernetz, Mats Ana, Vega Flanagan, James M. Tinker, Anna V. Stadler, Zsofia K. Hogervorst, Frans B. L. Ramus, Susan J. Teo, Soo-Hwang Ferguson, Sarah Kiiski, Johanna I. Leslie, Goska Hillemanns, Peter Fogarty, Zachary C. Birrer, Michael J. Huntsman, David G. Ganz, Patricia A. Fostira, Florentia Sucheston-Campbell, Lara E. Moes-Sosnowska, Joanna Paul, James Domchek, Susan M. van ensburg, Elizabeth J. Kupryjanczyk, Jolanta Pike, Malcolm C. Heetvelde, Mattias Van Bradbury, Angela R. Kim, Sung-Won Berchuck, Andrew Díez Gibert, Orland Azzollini, Jacopo Poppe, Bruce Menon, Usha Ness, Roberta B. May, Taymaa Teixeira, Manuel R. Prokofyeva, Darya Pugh, Elizabeth Eilber, Ursula Buecher, Bruno Holland, Helene Ding, Yuan Chun van der Hout, Annemarie H. Goldgar, David E. Ong, Kai Ren Dork, Thilo Eeles, Rosalind A. Giles, Graham G. Hulick, Peter J. Lázaro García, Conxi Szafron, Lukasz Brewer, Carole Thompson, Pamela J. Edwards, Todd L. Southey, Melissa C. Pedersen, Inge Søkilde Hein, Alexander Gentry-Maharaj, Aleksandra Ellis, Steve Hildebrandt, Mat Study EMBRACE Glasspool, Rosalind Peissel, Bernard Monteiro, Alvaro N. Aloisio, Aimee A. D’ Onland-Moret, N. Charlotte Piskorz, Anna M. Huzarski, Tomasz van Nieuwenhuysen, Els Tihomirova, Laima Neuhausen, Susan L. Chanock, Stephen J. Rothstein, Joseph H. Sandler, Dale P. Pujana Genestar, M. Ángel Dao, Fanny Brooks-Wilson, Angela R. Bean, Yukie Godwin, Andrew K. Mazoyer, Sylvie Webb, Penelope M. Richardson, Andrea Dansonka-Mieszkowska, Agnieszka Orsulic, Sandra Kjaer, Susanne Krüger Hahnen, Eric Pezzani, Lidia Nedergaard, Lotte Nussbaum, Robert L. Kwong, Ava Hazelett, Dennis Hooning, Maartje J. Merritt, Melissa A. Cook, Linda S. Risch, Harvey A. Kruse, Torben A. Palli, Domenico Lyra, Paulo C. Meijers-Heijboer, Hanne Coetzee, Simon Moysich, Kirsten B. Lele, Shashikant B. Lambrechts, Diether Zorn, Kristin K. Salvesen, Helga B. Szabo, Csilla I. Jensen, Allan Blankstein, Kenneth Lee, Jong Won Bjorge, Line Beesley, Jonathan Papi, Laura Delnatte, Capucine James, Paul Fortner, Renée T. Trabert, Britton Romm, Jane Shelford, Tameka Rennert, Gad Tung, Nadine Tworoger, Shelley S. Kennedy, Catherine J. Håkansson, Niclas Milne, Roger L. Janavicius, Ramunas Bernardini, Marcus Q. Lissowska, Jolanta Steinemann, Doris Jensen, Uffe Birk Liang, Dong Karnezis, Anthony N. Permuth, Jennifer B. Campbell, Ian Gore, Martin Thomassen, Mads Doheny, Kimberly F. Wu, Xifeng Tan, Yen Y. Butzow, Ralf Kiemeney, Lambertus A. L. M. McNeish, Iain Gerdes, Anne-Marie Liebrich, Clemens Tea, Muy-Kheng Edwards, Digna Velez Hunter, David J. Stoppa-Lyonnet, Dominique Tognazzo, Silvia Mulligan, Anna Marie Schmutzler, Rita Katharina Siddiqui, Nadeem Hodgson, Shirley Vratimos, Athanassios Wand, Dorothea van Altena, Anne M. Isaacs, Claudine Gruber, Stephen B. Park-Simon, Tjoung-Won Lipworth, Loren Brunet, Joan Vanderstichele, Adriaan Imyanitov, Evgeny N. Sukiennicki, Grzegorz Caldes, Trinidad Mai, Phuong L. Thomsen, Liv Cecilie Vestrheim Sharma, Priyanka Arver, Brita Peeters, Petra H. M. Mitchell, Gillian Anton-Culver, Hoda Hosking, Karen Daly, Mary B. Cannioto, Rikki Sutphen, Rebecca Dossus, Laure Rodriguez, Gustavo C. Durst, Matthias Schoemaker, Minouk J. Olopade, Olufunmilayo I. Chiew, Yoke-Eng Walsh, Christine Schildkraut, Joellen M. Odunsi, Kunle Henderson, Alex Pfeiler, Georg Garcia, Maria Jose Dworniczak, Bernd Sutter, Christian Nevanlinna, Heli Lecarpentier, Julie Goode, Ellen L. Garber, Judy Wentzensen, Nicolas Barjhoux, Laure Gayther, Simon A. Antoniou, Antonis C. Orr, Nicholas Manoukian, Siranoush Niederacher, Dieter Vergote, Ignace Prieur, Fabienne Larson, Melissa C. Olah, Edith Pocza, Timea Andrulis, Irene L. Terry, Kathryn L. Harris, Holly R. Lubinski, Jan Jakubowska, Anna Cescon, Terence Ottini, Laura Hamann, Ute Osorio, Ana Robson, Mark Levine, Douglas A. Poole, Elizabeth M. Park, Sue K. Bojesen, Anders Ziogas, Argyrios Couch, Fergus J. Senter, Leigha Caligo, Maria A. Whittemore, Alice Meindl, Alfons Brenton, James D. Broberg, Per Pharoah, Paul D. P. Nathanson, Katherine L. Swerdlow, Anthony J. Porteous, Mary E. Haiman, Christopher A. Blok, Marinus J. Musinsky, Jacob Beckmann, Matthias W. McGuffog, Lesley Pujol, Pascal Offit, Kenneth Weitzel, Jeffrey N. Taylor, Jack A. Rudolph, Anja Fasching, Peter A. Modugno, Francesmary Friebel, Tara M. Hauke, Jan Narod, Steven A. John, Esther M. Durán, Mercedes Jones, Michael E. Song, Honglin Høgdall, Estrid Brinton, Louise A. Conner, Thomas Singer, Christian F. McLaughlin, John R. Thull, Darcy L. Leroux, Dominique Kannisto, Päivi Easton, Douglas F. Ekici, Arif B. Larrañaga, Nerea Leminen, Arto Aben, Katja K. Fountzilas, George Yang, Hannah Moffitt, Melissa Ejlertsen, Bent Rantala, Johanna Sieh, Weiva Trichopoulou, Antonia Pelttari, Liisa M. Sobol, Hagay Tone, Alicia Evans, D. Gareth Beeghly-Fadiel, Alicia McAlpine, Jessica N. Aravantinos, Gerasimos Adlard, Julian Gehrig, Andrea Massuger, Leon F. A. G. Rossing, Mary Anne Adams, Marcia Poblete, Samantha R. Banerjee, Susana N. Cunningham, Julie M. Glendon, Gord Chen, Xiao Qing Defazio, Anna Wappenschmidt, Barbara Buys, Saundra S. Rodriguez Antona, Cristina Goranova, Teodora Gronwald, Jacek Dorfling, Cecilia M. Severi, Gianluca Amos, Christopher I. Travis, Ruth C. Mendoza-Fandino, Gustavo A. Vierkant, Robert A. Friedman, Eitan Eccles, Diana van den Berg, David Berg, David Damirovna, Sakaeva Dina Varon-Mateeva, Raymonda Goodman, Marc T. Barkardottir, Rosa B. Kopperud, Reidun K. Runnebaum, Ingo B. Le, Nhu D. Chiquette, Jocelyne Davidson, Rosemarie Johnatty, Sharon Olswold, Curtis Woo, Michelle Mensenkamp, Arjen R. Greene, Mark H. Doherty, Jennifer A. Wilkens, Lynne R. Arnold, Norbert Piedmonte, Marion O'Malley, David M. Chung, Wendy K. Barrowdale, Daniel Pejovic, Tanja Antonenkova, Natalia N. Elvira, Mingajeva Garcia Barberan, Vanesa Chang-Claude, Jenny Arun, Banu K. van der Luijt, Rob B. Wijnen, Juul Sellers, Thomas A. Balmaña, Judith Wolk, Alicja Chenevix-Trench, Georgia Kobel, Martin Frost, Debra Rice, Patricia Ferrer, Sandra Fert Lester, Jenny Rappaport-Fuerhauser, Christine Vijai, Joseph Eng, Kevin H. Toland, Amanda Ewart Foulkes, William D. Hung, Jillian Lilyquist, Jenna Høgdall, Claus K. Izatt, Louise Hansen, Thomas V. O. Peixoto, Ana Lu, Karen H. Luccarini, Craig Lee, Andrew Weinberg, Clarice R. Claes, Kathleen B. M. Benitez, Javier Radice, Paolo Borg, Åke Karlan, Beth Y. Bermisheva, Marina Dicks, Ed Bodelon, Clara Cramer, Daniel W. Fridley, Brooke L. Pearce, Celeste L. Walker, Lisa Peterlongo, Paolo Soucy, Penny Olsson, Håkan Spurdle, Amanda B. Carney, Michael E. Rookus, Matti A. Aalfs, Cora M. |
Keywords: | Càncer d'ovari Ovarian cancer |
Issue Date: | 1-May-2017 |
Publisher: | Nature Publishing |
Abstract: | To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826 |
It is part of: | Nature Genetics, 2017, vol. 49, num. 5, p. 680-691 |
URI: | https://hdl.handle.net/2445/124402 |
Related resource: | https://doi.org/10.1038/ng.3826 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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