Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Phelan, Catherine M.; Kuchenbaecker, Karoline B.; Tyrer, Jonathan P.; Kar, Siddhartha P.; Lawrenson, Kate; Winham, Stacey J.; Dennis, Joe; Pirie, Ailith; Riggan, Marjorie J.; Chornokur, Ganna; Earp, Madalene A.; Hildebrandt, Mat; Study EMBRACE; Glasspool, Rosalind; Peissel, Bernard; Monteiro, Alvaro N.; Aloisio, Aimee A. D’; Onland-Moret, N. Charlotte; Piskorz, Anna M.; Huzarski, Tomasz; van Nieuwenhuysen, Els; Chan, Salina B.; Tihomirova, Laima; Neuhausen, Susan L.; Chanock, Stephen J.; Rothstein, Joseph H.; Sandler, Dale P.; Pujana Genestar, M. Ángel; Dao, Fanny; Brooks-Wilson, Angela R.; Bean, Yukie; Godwin, Andrew K.; Huang, Ruea-Yea; Mazoyer, Sylvie; Webb, Penelope M.; Richardson, Andrea; Dansonka-Mieszkowska, Agnieszka; Orsulic, Sandra; Kjaer, Susanne Krüger; Hahnen, Eric; Pezzani, Lidia; Nedergaard, Lotte; Nussbaum, Robert L.; Bogdanova, Natalia V.; Kwong, Ava; Hazelett, Dennis; Hooning, Maartje J.; Merritt, Melissa A.; Cook, Linda S.; Risch, Harvey A.; Kruse, Torben A.; Palli, Domenico; Lyra, Paulo C.; Meijers-Heijboer, Hanne; Laitman, Yael; Coetzee, Simon; Moysich, Kirsten B.; Lele, Shashikant B.; Lambrechts, Diether; Zorn, Kristin K.; Salvesen, Helga B.; Szabo, Csilla I.; Jensen, Allan; Blankstein, Kenneth; Lee, Jong Won; Tischkowitz, Marc; Bjorge, Line; Beesley, Jonathan; Papi, Laura; Delnatte, Capucine; James, Paul; Fortner, Renée T.; Trabert, Britton; Romm, Jane; Shelford, Tameka; Rennert, Gad; Kelemen, Linda E.; Tung, Nadine; Tworoger, Shelley S.; Kennedy, Catherine J.; Håkansson, Niclas; Milne, Roger L.; Janavicius, Ramunas; Bernardini, Marcus Q.; Lissowska, Jolanta; Steinemann, Doris; Jensen, Uffe Birk; Kast, Karin; Liang, Dong; Karnezis, Anthony N.; Permuth, Jennifer B.; Campbell, Ian; Gore, Martin; Thomassen, Mads; Doheny, Kimberly F.; Wu, Xifeng; Tan, Yen Y.; Butzow, Ralf; Lesueur, Fabienne; Kiemeney, Lambertus A. L. M.; McNeish, Iain; Gerdes, Anne-Marie; Liebrich, Clemens; Tea, Muy-Kheng; Edwards, Digna Velez; Hunter, David J.; Stoppa-Lyonnet, Dominique; Tognazzo, Silvia; Mulligan, Anna Marie; Black, Amanda; Schmutzler, Rita Katharina; Siddiqui, Nadeem; Hodgson, Shirley; Vratimos, Athanassios; Wand, Dorothea; van Altena, Anne M.; Isaacs, Claudine; Gruber, Stephen B.; Park-Simon, Tjoung-Won; Lipworth, Loren; Rhiem, Kerstin; Brunet, Joan; Vanderstichele, Adriaan; Imyanitov, Evgeny N.; Sukiennicki, Grzegorz; Caldes, Trinidad; Mai, Phuong L.; Thomsen, Liv Cecilie Vestrheim; Sharma, Priyanka; Arver, Brita; Peeters, Petra H. M.; Wu, Anna H.; Mitchell, Gillian; Anton-Culver, Hoda; Hosking, Karen; Daly, Mary B.; Cannioto, Rikki; Sutphen, Rebecca; Dossus, Laure; Rodriguez, Gustavo C.; Durst, Matthias; Schoemaker, Minouk J.; Phillips, Kelly-Anne; Olopade, Olufunmilayo I.; Chiew, Yoke-Eng; Walsh, Christine; Schildkraut, Joellen M.; Odunsi, Kunle; Henderson, Alex; Pfeiler, Georg; Garcia, Maria Jose; Dworniczak, Bernd; Sutter, Christian; Izquierdo i Font, Àngel Xavier; Nevanlinna, Heli; Lecarpentier, Julie; Goode, Ellen L.; Garber, Judy; Wentzensen, Nicolas; Barjhoux, Laure; Gayther, Simon A.; Antoniou, Antonis C.; Orr, Nicholas; Manoukian, Siranoush; Yannoukakos, Drakoulis; Niederacher, Dieter; Vergote, Ignace; Prieur, Fabienne; Larson, Melissa C.; Olah, Edith; Pocza, Timea; Andrulis, Irene L.; Terry, Kathryn L.; Harris, Holly R.; Lubinski, Jan; Damiola, Francesca; Jakubowska, Anna; Cescon, Terence; Ottini, Laura; Hamann, Ute; Osorio, Ana; Robson, Mark; Levine, Douglas A.; Poole, Elizabeth M.; Park, Sue K.; Bojesen, Anders; Montagna, Marco; Ziogas, Argyrios; Couch, Fergus J.; Senter, Leigha; Caligo, Maria A.; Whittemore, Alice; Meindl, Alfons; Brenton, James D.; Broberg, Per; Pharoah, Paul D. P.; Nathanson, Katherine L.; Lundvall, Lene; Swerdlow, Anthony J.; Porteous, Mary E.; Haiman, Christopher A.; Blok, Marinus J.; Musinsky, Jacob; Beckmann, Matthias W.; McGuffog, Lesley; Pujol, Pascal; Offit, Kenneth; Weitzel, Jeffrey N.; Lee, Janet M.; Taylor, Jack A.; Rudolph, Anja; Fasching, Peter A.; Modugno, Francesmary; Friebel, Tara M.; Hauke, Jan; Narod, Steven A.; John, Esther M.; Durán, Mercedes; Jones, Michael E.; Wang-Gohrke, Shan; Song, Honglin; Høgdall, Estrid; Brinton, Louise A.; Conner, Thomas; Singer, Christian F.; McLaughlin, John R.; Thull, Darcy L.; Leroux, Dominique; Kannisto, Päivi; Easton, Douglas F.; Side, Lucy E.; Ekici, Arif B.; Larrañaga, Nerea; Leminen, Arto; Aben, Katja K.; Fountzilas, George; Yang, Hannah; Moffitt, Melissa; Ejlertsen, Bent; Rantala, Johanna; Sieh, Weiva; Bonanni, Bernardo; Trichopoulou, Antonia; Pelttari, Liisa M.; Sobol, Hagay; Tone, Alicia; Evans, D. Gareth; Beeghly-Fadiel, Alicia; McAlpine, Jessica N.; Aravantinos, Gerasimos; Adlard, Julian; Gehrig, Andrea; Cook, Jackie; Massuger, Leon F. A. G.; Rossing, Mary Anne; Adams, Marcia; Poblete, Samantha R.; Banerjee, Susana; Cunningham, Julie M.; Glendon, Gord; Chen, Xiao Qing; Defazio, Anna; Wappenschmidt, Barbara; Harrington, Patricia A.; Buys, Saundra S.; Rodriguez Antona, Cristina; Goranova, Teodora; Gronwald, Jacek; Dorfling, Cecilia M.; Severi, Gianluca; Amos, Christopher I.; Travis, Ruth C.; Mendoza-Fandino, Gustavo A.; Vierkant, Robert A.; Setiawan, V. Wendy; Friedman, Eitan; Eccles, Diana; van den Berg, David  Berg, David; Damirovna, Sakaeva Dina; Varon-Mateeva, Raymonda; Goodman, Marc T.; Barkardottir, Rosa B.; Kopperud, Reidun K.; Runnebaum, Ingo B.; Le, Nhu D.; McGuire, Valerie; Chiquette, Jocelyne; Davidson, Rosemarie; Johnatty, Sharon; Olswold, Curtis; Woo, Michelle; Mensenkamp, Arjen R.; Greene, Mark H.; Doherty, Jennifer A.; Wilkens, Lynne R.; Arnold, Norbert; Simard, Jacques; Piedmonte, Marion; O'Malley, David M.; Chung, Wendy K.; Barrowdale, Daniel; Pejovic, Tanja; Antonenkova, Natalia N.; Elvira, Mingajeva; Garcia Barberan, Vanesa; Chang-Claude, Jenny; Arun, Banu K.; Khusnutdinova, Elza; van der Luijt, Rob B.; Wijnen, Juul; Sellers, Thomas A.; Balmaña, Judith; Wolk, Alicja; Chenevix-Trench, Georgia; Kobel, Martin; Frost, Debra; Rice, Patricia; Ferrer, Sandra Fert; Engel, Christoph; Lester, Jenny; Rappaport-Fuerhauser, Christine; Vijai, Joseph; Eng, Kevin H.; Toland, Amanda Ewart; Foulkes, William D.; Hung, Jillian; Lilyquist, Jenna; Høgdall, Claus K.; Izatt, Louise; Bruinsma, Fiona; Hansen, Thomas V. O.; Peixoto, Ana; Lu, Karen H.; Luccarini, Craig; Lee, Andrew; Weinberg, Clarice R.; Claes, Kathleen B. M.; Benitez, Javier; Radice, Paolo; Borg, Åke; Marchand, Loïc Le; Karlan, Beth Y.; Bermisheva, Marina; Dicks, Ed; Bodelon, Clara; Cramer, Daniel W.; Fridley, Brooke L.; Pearce, Celeste L.; Walker, Lisa; Peterlongo, Paolo; Soucy, Penny; Iversen, Edwin S.; Olsson, Håkan; Spurdle, Amanda B.; Carney, Michael E.; Rookus, Matti A.; Aalfs, Cora M.; Jernetz, Mats; Ana, Vega; Flanagan, James M.; Tinker, Anna V.; Stadler, Zsofia K.; Hogervorst, Frans B. L.; Ramus, Susan J.; Teo, Soo-Hwang; Ferguson, Sarah; Kiiski, Johanna I.; Leslie, Goska; Hillemanns, Peter; Fogarty, Zachary C.; Birrer, Michael J.; Huntsman, David G.; Ganz, Patricia A.; Fostira, Florentia; Sucheston-Campbell, Lara E.; Moes-Sosnowska, Joanna; Paul, James; Domchek, Susan M.; van ensburg, Elizabeth J.; Kupryjanczyk, Jolanta; Pike, Malcolm C.; Heetvelde, Mattias Van; Bradbury, Angela R.; Kim, Sung-Won; Berchuck, Andrew; Díez Gibert, Orland; Azzollini, Jacopo; Poppe, Bruce; Menon, Usha; Ness, Roberta B.; May, Taymaa; Teixeira, Manuel R.; Prokofyeva, Darya; Pugh, Elizabeth; Eilber, Ursula; Buecher, Bruno; Holland, Helene; Ding, Yuan Chun; van der Hout, Annemarie H.; Goldgar, David E.; Ong, Kai Ren; Dork, Thilo; Eeles, Rosalind A.; Giles, Graham G.; Hulick, Peter J.; Lázaro García, Conxi; Szafron, Lukasz; Brewer, Carole; Thompson, Pamela J.; Edwards, Todd L.; Southey, Melissa C.; Pedersen, Inge Søkilde; Hein, Alexander; Gentry-Maharaj, Aleksandra; Ellis, Steve

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124402

Title:	Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Author:	Phelan, Catherine M. Kuchenbaecker, Karoline B. Tyrer, Jonathan P. Kar, Siddhartha P. Lawrenson, Kate Winham, Stacey J. Dennis, Joe Pirie, Ailith Riggan, Marjorie J. Chornokur, Ganna Earp, Madalene A. Hildebrandt, Mat Study EMBRACE Glasspool, Rosalind Peissel, Bernard Monteiro, Alvaro N. Aloisio, Aimee A. D’ Onland-Moret, N. Charlotte Piskorz, Anna M. Huzarski, Tomasz van Nieuwenhuysen, Els Chan, Salina B. Tihomirova, Laima Neuhausen, Susan L. Chanock, Stephen J. Rothstein, Joseph H. Sandler, Dale P. Pujana Genestar, M. Ángel Dao, Fanny Brooks-Wilson, Angela R. Bean, Yukie Godwin, Andrew K. Huang, Ruea-Yea Mazoyer, Sylvie Webb, Penelope M. Richardson, Andrea Dansonka-Mieszkowska, Agnieszka Orsulic, Sandra Kjaer, Susanne Krüger Hahnen, Eric Pezzani, Lidia Nedergaard, Lotte Nussbaum, Robert L. Bogdanova, Natalia V. Kwong, Ava Hazelett, Dennis Hooning, Maartje J. Merritt, Melissa A. Cook, Linda S. Risch, Harvey A. Kruse, Torben A. Palli, Domenico Lyra, Paulo C. Meijers-Heijboer, Hanne Laitman, Yael Coetzee, Simon Moysich, Kirsten B. Lele, Shashikant B. Lambrechts, Diether Zorn, Kristin K. Salvesen, Helga B. Szabo, Csilla I. Jensen, Allan Blankstein, Kenneth Lee, Jong Won Tischkowitz, Marc Bjorge, Line Beesley, Jonathan Papi, Laura Delnatte, Capucine James, Paul Fortner, Renée T. Trabert, Britton Romm, Jane Shelford, Tameka Rennert, Gad Kelemen, Linda E. Tung, Nadine Tworoger, Shelley S. Kennedy, Catherine J. Håkansson, Niclas Milne, Roger L. Janavicius, Ramunas Bernardini, Marcus Q. Lissowska, Jolanta Steinemann, Doris Jensen, Uffe Birk Kast, Karin Liang, Dong Karnezis, Anthony N. Permuth, Jennifer B. Campbell, Ian Gore, Martin Thomassen, Mads Doheny, Kimberly F. Wu, Xifeng Tan, Yen Y. Butzow, Ralf Lesueur, Fabienne Kiemeney, Lambertus A. L. M. McNeish, Iain Gerdes, Anne-Marie Liebrich, Clemens Tea, Muy-Kheng Edwards, Digna Velez Hunter, David J. Stoppa-Lyonnet, Dominique Tognazzo, Silvia Mulligan, Anna Marie Black, Amanda Schmutzler, Rita Katharina Siddiqui, Nadeem Hodgson, Shirley Vratimos, Athanassios Wand, Dorothea van Altena, Anne M. Isaacs, Claudine Gruber, Stephen B. Park-Simon, Tjoung-Won Lipworth, Loren Rhiem, Kerstin Brunet, Joan Vanderstichele, Adriaan Imyanitov, Evgeny N. Sukiennicki, Grzegorz Caldes, Trinidad Mai, Phuong L. Thomsen, Liv Cecilie Vestrheim Sharma, Priyanka Arver, Brita Peeters, Petra H. M. Wu, Anna H. Mitchell, Gillian Anton-Culver, Hoda Hosking, Karen Daly, Mary B. Cannioto, Rikki Sutphen, Rebecca Dossus, Laure Rodriguez, Gustavo C. Durst, Matthias Schoemaker, Minouk J. Phillips, Kelly-Anne Olopade, Olufunmilayo I. Chiew, Yoke-Eng Walsh, Christine Schildkraut, Joellen M. Odunsi, Kunle Henderson, Alex Pfeiler, Georg Garcia, Maria Jose Dworniczak, Bernd Sutter, Christian Izquierdo i Font, Àngel Xavier Nevanlinna, Heli Lecarpentier, Julie Goode, Ellen L. Garber, Judy Wentzensen, Nicolas Barjhoux, Laure Gayther, Simon A. Antoniou, Antonis C. Orr, Nicholas Manoukian, Siranoush Yannoukakos, Drakoulis Niederacher, Dieter Vergote, Ignace Prieur, Fabienne Larson, Melissa C. Olah, Edith Pocza, Timea Andrulis, Irene L. Terry, Kathryn L. Harris, Holly R. Lubinski, Jan Damiola, Francesca Jakubowska, Anna Cescon, Terence Ottini, Laura Hamann, Ute Osorio, Ana Robson, Mark Levine, Douglas A. Poole, Elizabeth M. Park, Sue K. Bojesen, Anders Montagna, Marco Ziogas, Argyrios Couch, Fergus J. Senter, Leigha Caligo, Maria A. Whittemore, Alice Meindl, Alfons Brenton, James D. Broberg, Per Pharoah, Paul D. P. Nathanson, Katherine L. Lundvall, Lene Swerdlow, Anthony J. Porteous, Mary E. Haiman, Christopher A. Blok, Marinus J. Musinsky, Jacob Beckmann, Matthias W. McGuffog, Lesley Pujol, Pascal Offit, Kenneth Weitzel, Jeffrey N. Lee, Janet M. Taylor, Jack A. Rudolph, Anja Fasching, Peter A. Modugno, Francesmary Friebel, Tara M. Hauke, Jan Narod, Steven A. John, Esther M. Durán, Mercedes Jones, Michael E. Wang-Gohrke, Shan Song, Honglin Høgdall, Estrid Brinton, Louise A. Conner, Thomas Singer, Christian F. McLaughlin, John R. Thull, Darcy L. Leroux, Dominique Kannisto, Päivi Easton, Douglas F. Side, Lucy E. Ekici, Arif B. Larrañaga, Nerea Leminen, Arto Aben, Katja K. Fountzilas, George Yang, Hannah Moffitt, Melissa Ejlertsen, Bent Rantala, Johanna Sieh, Weiva Bonanni, Bernardo Trichopoulou, Antonia Pelttari, Liisa M. Sobol, Hagay Tone, Alicia Evans, D. Gareth Beeghly-Fadiel, Alicia McAlpine, Jessica N. Aravantinos, Gerasimos Adlard, Julian Gehrig, Andrea Cook, Jackie Massuger, Leon F. A. G. Rossing, Mary Anne Adams, Marcia Poblete, Samantha R. Banerjee, Susana Cunningham, Julie M. Glendon, Gord Chen, Xiao Qing Defazio, Anna Wappenschmidt, Barbara Harrington, Patricia A. Buys, Saundra S. Rodriguez Antona, Cristina Goranova, Teodora Gronwald, Jacek Dorfling, Cecilia M. Severi, Gianluca Amos, Christopher I. Travis, Ruth C. Mendoza-Fandino, Gustavo A. Vierkant, Robert A. Setiawan, V. Wendy Friedman, Eitan Eccles, Diana van den Berg, David Berg, David Damirovna, Sakaeva Dina Varon-Mateeva, Raymonda Goodman, Marc T. Barkardottir, Rosa B. Kopperud, Reidun K. Runnebaum, Ingo B. Le, Nhu D. McGuire, Valerie Chiquette, Jocelyne Davidson, Rosemarie Johnatty, Sharon Olswold, Curtis Woo, Michelle Mensenkamp, Arjen R. Greene, Mark H. Doherty, Jennifer A. Wilkens, Lynne R. Arnold, Norbert Simard, Jacques Piedmonte, Marion O'Malley, David M. Chung, Wendy K. Barrowdale, Daniel Pejovic, Tanja Antonenkova, Natalia N. Elvira, Mingajeva Garcia Barberan, Vanesa Chang-Claude, Jenny Arun, Banu K. Khusnutdinova, Elza van der Luijt, Rob B. Wijnen, Juul Sellers, Thomas A. Balmaña, Judith Wolk, Alicja Chenevix-Trench, Georgia Kobel, Martin Frost, Debra Rice, Patricia Ferrer, Sandra Fert Engel, Christoph Lester, Jenny Rappaport-Fuerhauser, Christine Vijai, Joseph Eng, Kevin H. Toland, Amanda Ewart Foulkes, William D. Hung, Jillian Lilyquist, Jenna Høgdall, Claus K. Izatt, Louise Bruinsma, Fiona Hansen, Thomas V. O. Peixoto, Ana Lu, Karen H. Luccarini, Craig Lee, Andrew Weinberg, Clarice R. Claes, Kathleen B. M. Benitez, Javier Radice, Paolo Borg, Åke Marchand, Loïc Le Karlan, Beth Y. Bermisheva, Marina Dicks, Ed Bodelon, Clara Cramer, Daniel W. Fridley, Brooke L. Pearce, Celeste L. Walker, Lisa Peterlongo, Paolo Soucy, Penny Iversen, Edwin S. Olsson, Håkan Spurdle, Amanda B. Carney, Michael E. Rookus, Matti A. Aalfs, Cora M. Jernetz, Mats Ana, Vega Flanagan, James M. Tinker, Anna V. Stadler, Zsofia K. Hogervorst, Frans B. L. Ramus, Susan J. Teo, Soo-Hwang Ferguson, Sarah Kiiski, Johanna I. Leslie, Goska Hillemanns, Peter Fogarty, Zachary C. Birrer, Michael J. Huntsman, David G. Ganz, Patricia A. Fostira, Florentia Sucheston-Campbell, Lara E. Moes-Sosnowska, Joanna Paul, James Domchek, Susan M. van ensburg, Elizabeth J. Kupryjanczyk, Jolanta Pike, Malcolm C. Heetvelde, Mattias Van Bradbury, Angela R. Kim, Sung-Won Berchuck, Andrew Díez Gibert, Orland Azzollini, Jacopo Poppe, Bruce Menon, Usha Ness, Roberta B. May, Taymaa Teixeira, Manuel R. Prokofyeva, Darya Pugh, Elizabeth Eilber, Ursula Buecher, Bruno Holland, Helene Ding, Yuan Chun van der Hout, Annemarie H. Goldgar, David E. Ong, Kai Ren Dork, Thilo Eeles, Rosalind A. Giles, Graham G. Hulick, Peter J. Lázaro García, Conxi Szafron, Lukasz Brewer, Carole Thompson, Pamela J. Edwards, Todd L. Southey, Melissa C. Pedersen, Inge Søkilde Hein, Alexander Gentry-Maharaj, Aleksandra Ellis, Steve
Keywords:	Càncer d'ovari Ovarian cancer
Issue Date:	1-May-2017
Publisher:	Nature Publishing
Abstract:	To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Note:	Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826
It is part of:	Nature Genetics, 2017, vol. 49, num. 5, p. 680-691
URI:	https://hdl.handle.net/2445/124402
Related resource:	https://doi.org/10.1038/ng.3826
Appears in Collections:	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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