Title: | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer |
Author: | Phelan, Catherine M. Kuchenbaecker, Karoline B. Tyrer, Jonathan P. Kar, Siddhartha P. Lawrenson, Kate Winham, Stacey J. Dennis, Joe Pirie, Ailith Riggan, Marjorie Chornokur, Ganna Earp, Madalene A. Leroux, Dominique Spurdle, Amanda B. Jensen, Allan Tworoger, Shelley S. Wu, Xifeng Hodgson, Shirley Thomsen, Liv Cecilie Vestrheim Chiew, Yoke-Eng Caligo, Maria A. Tihomirova, Laima Garcia, Maria Jose Prieur, Fabienne Levine, Douglas A. Swerdlow, Anthony J. Friebel, Tara M. Peixoto, Ana Moysich, Kirsten B. Conner, Thomas Sieh, Weiva Banerjee, Susana N. Mendoza-Fandino, Gustavo A. Olswold, Curtis Lele, Shashikant B. Thull, Darcy L. Antonenkova, Natalia N. Ferrer, Sandra Fert Lee, Andrew Soucy, Penny Black, Amanda Khusnutdinova, Elza Leslie, Goska Paul, James Domchek, Susan M. van ensburg, Elizabeth J. Heetvelde, Mattias Van Bradbury, Angela R. Kim, Sung-Won Azzollini, Jacopo Poppe, Bruce Menon, Usha Ness, Roberta B. May, Taymaa Prokofyeva, Darya Pugh, Elizabeth Buecher, Bruno Ding, Yuan Chun Goldgar, David E. Ong, Kai Ren Dork, Thilo Giles, Graham G. Hulick, Peter J. Lázaro García, Conxi Szafron, Lukasz Brewer, Carole Southey, Melissa C. Hein, Alexander Ellis, Steve Hildebrandt, Mat Study EMBRACE Glasspool, Rosalind Peissel, Bernard Monteiro, Alvaro N. Onland-Moret, N. Charlotte Piskorz, Anna M. Neuhausen, Susan L. Chanock, Stephen J. Rothstein, Joseph H. Sandler, Dale P. Pujana Genestar, M. Ángel Dao, Fanny Bean, Yukie Godwin, Andrew K. Webb, Penelope M. Richardson, Andrea Kjaer, Susanne Krüger Hahnen, Eric Pezzani, Lidia Nedergaard, Lotte Kwong, Ava Hooning, Maartje J. Merritt, Melissa A. Cook, Linda S. Risch, Harvey A. Palli, Domenico Meijers-Heijboer, Hanne Coetzee, Simon Lambrechts, Diether Zorn, Kristin K. Salvesen, Helga B. Piedmonte, Marion Pedersen, Inge Søkilde Odunsi, Kunle Antoniou, Antonis C. Cescon, Terence Meindl, Alfons Offit, Kenneth Høgdall, Estrid Harrington, Patricia A. Schmutzler, Rita Katharina Trichopoulou, Antonia Poblete, Samantha R. Amos, Christopher I. Le, Nhu D. Teixeira, Manuel R. Schoemaker, Minouk J. Doherty, Jennifer Anne Wijnen, Juul Foulkes, William D. Radice, Paolo Phillips, Kelly-Anne Simard, Jacques Ferguson, Sarah Kupryjanczyk, Jolanta Eilber, Ursula Edwards, Todd Huzarski, Tomasz Orsulic, Sandra Lyra, Paulo C. Szabo, Csilla I. Blankstein, Kenneth Bjorge, Line Beesley, Jonathan Papi, Laura Fortner, Renée T. Trabert, Britton Romm, Jane Shelford, Tameka Rennert, Gad Tung, Nadine Håkansson, Niclas Janavicius, Ramunas Lissowska, Jolanta Steinemann, Doris Jensen, Uffe Birk Liang, Dong Karnezis, Anthony N. Permuth, Jennifer B. Campbell, Ian Gore, Martin Butzow, Ralf Kiemeney, Lambertus A. L. M. McNeish, Iain Gerdes, Anne-Marie Liebrich, Clemens Tea, Muy-Kheng Edwards, Digna Velez Stoppa-Lyonnet, Dominique Tognazzo, Silvia Siddiqui, Nadeem Vratimos, Athanassios Wand, Dorothea van Altena, Anne M. Isaacs, Claudine Park-Simon, Tjoung-Won Lipworth, Loren Brunet, Joan Vanderstichele, Adriaan Caldes, Trinidad Mai, Phuong L. Sharma, Priyanka Peeters, Petra H. M. Mitchell, Gillian Anton-Culver, Hoda Hosking, Karen Daly, Mary B. Sutphen, Rebecca Rodriguez, Gustavo C. Durst, Matthias Olopade, Olufunmilayo I. Walsh, Christine Tinker, Anna V. Tan, Yen Y. Singer, Christian F. Moffitt, Melissa Gehrig, Andrea Rodriguez Antona, Cristina Damirovna, Sakaeva Dina Mensenkamp, Arjen R. Mazoyer, Sylvie Sellers, Thomas A. Toland, Amanda Ewart Claes, Kathleen B. M. Peterlongo, Paolo Kelemen, Linda E. Wang-Gohrke, Shan Jernetz, Mats Huntsman, David G. Díez Gibert, Orland van der Hout, Annemarie H. Dansonka-Mieszkowska, Agnieszka Kruse, Torben A. Lee, Jong Won Kennedy, Catherine J. Doheny, Kimberly F Mulligan, Anna Marie Sukiennicki, Grzegorz Dossus, Laure Schildkraut, Joellen M. Henderson, Alex Dworniczak, Bernd Sutter, Christian Lecarpentier, Julie Goode, Ellen L. Garber, Judy Wentzensen, Nicolas Barjhoux, Laure Gayther, Simon A. Manoukian, Siranoush Niederacher, Dieter Larson, Melissa C. Olah, Edith Pocza, Timea Andrulis, Irene L. Terry, Kathryn L. Harris, Holly R. Lubinski, Jan Hamann, Ute Osorio, Ana Robson, Mark Poole, Elizabeth M. Park, Sue K. Bojesen, Anders Ziogas, Argyrios Couch, Fergus J. Whittemore, Alice Brenton, James D. Broberg, Per Pharoah, Paul D. P. Nathanson, Katherine L. Porteous, Mary E. Haiman, Christopher A. Blok, Marinus J. McGuffog, Lesley Pujol, Pascal Weitzel, Jeffrey N. Taylor, Jack A. Rudolph, Anja Fasching, Peter A. Modugno, Francesmary Narod, Steven A. Durán, Mercedes Jones, Michael E. Song, Honglin Brinton, Louise A. Hazelett, Dennis Ottini, Laura Wilkens, Lynne R. Arun, Banu K. Lester, Jenny Dicks, Ed Rookus, Matti A. Rhiem, Kerstin Ganz, Patricia A. Berchuck, Andrew Holland, Helene Thompson, Pamela J. Aloisio, Aimee A. D’ Brooks-Wilson, Angela R. Nussbaum, Robert L. James, Paul Bernardini, Marcus Q. Imyanitov, Evgeny N. Cannioto, Rikki Pfeiler, Georg Orr, Nicholas Jakubowska, Anna Senter, Leigha Beckmann, Matthias W. John, Esther M. McLaughlin, John R. Kannisto, Päivi Easton, Douglas F. Ekici, Arif B. Larrañaga, Nerea Leminen, Arto Aben, Katja K. Fountzilas, George Yang, Hannah Rantala, Johanna Pelttari, Liisa M. Sobol, Hagay Tone, Alicia Evans, D. Gareth Beeghly-Fadiel, Alicia McAlpine, Jessica N. Aravantinos, Gerasimos Massuger, Leon F. A. G. Rossing, Mary Anne Adams, Marcia Cunningham, Julie M. Glendon, Gord Chen, Xiao Qing Defazio, Anna Buys, Saundra S. Goranova, Teodora Gronwald, Jacek Dorfling, Cecilia M. Severi, Gianluca Travis, Ruth C. Vierkant, Robert A. Eccles, Diana van den Berg, David Berg, David Varon-Mateeva, Raymonda Goodman, Marc T. Barkardottir, Rosa B. Kopperud, Reidun K. Runnebaum, Ingo B. Chiquette, Jocelyne Johnatty, Sharon Woo, Michelle Greene, Mark H. Wu, Anna H. Cook, Jackie Ana, Vega Fogarty, Zachary C. Pike, Malcolm C. Eeles, Rosalind A. Gentry-Maharaj, Aleksandra van Nieuwenhuysen, Els Delnatte, Capucine Milne, Roger L. Thomassen, Mads Hunter, David J. Gruber, Stephen B. Arver, Brita Nevanlinna, Heli Vergote, Ignace Musinsky, Jacob Hauke, Jan Ejlertsen, Bent Adlard, Julian Wappenschmidt, Barbara Friedman, Eitan Davidson, Rosemarie Arnold, Norbert O'Malley, David M. Chung, Wendy K. Barrowdale, Daniel Pejovic, Tanja Elvira, Mingajeva Garcia Barberan, Vanesa Chang-Claude, Jenny van der Luijt, Rob B. Balmaña, Judith Wolk, Alicja Chenevix-Trench, Georgia Kobel, Martin Frost, Debra Rice, Patricia Rappaport-Fuerhauser, Christine Vijai, Joseph Eng, Kevin H. Hung, Jillian Lilyquist, Jenna Høgdall, Claus K. Izatt, Louise Hansen, Thomas V. O. Lu, Karen H. Luccarini, Craig Weinberg, Clarice R. Benitez, Javier Borg, Åke Karlan, Beth Y. Bermisheva, Marina Bodelon, Clara Cramer, Daniel W. Fridley, Brooke L. Pearce, Celeste L. Walker, Lisa Olsson, Håkan Carney, Michael E. Aalfs, Cora M. Chan, Salina B. Huang, Ruea-Yea Bogdanova, Natalia V. Laitman, Yael Tischkowitz, Marc Kast, Karin Lesueur, Fabienne Izquierdo i Font, Àngel Xavier Yannoukakos, Drakoulis Damiola, Francesca Montagna, Marco Lundvall, Lene Lee, Janet M. Side, Lucy E. Bonanni, Bernardo Setiawan, V. Wendy McGuire, Valerie Engel, Christoph Bruinsma, Fiona Marchand, Loïc Le Iversen, Edwin S. Flanagan, James M. Stadler, Zsofia Hogervorst, Frans B. L. Ramus, Susan J. Teo, Soo-Hwang Kiiski, Johanna I. Hillemanns, Peter Birrer, Michael J. Fostira, Florentia Sucheston-Campbell, Lara E. Moes-Sosnowska, Joanna |
Keywords: | Càncer d'ovari Ovarian cancer |
Issue Date: | 1-May-2017 |
Publisher: | Nature Publishing |
Abstract: | To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826 |
It is part of: | Nature Genetics, 2017, vol. 49, num. 5, p. 680-691 |
URI: | http://hdl.handle.net/2445/124402 |
Related resource: | https://doi.org/10.1038/ng.3826 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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