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http://hdl.handle.net/2445/124410
Title: | Human papillomavirus 16 is an aetiological factor of scrotal cancer |
Author: | Guimerà, Núria Alemany i Vilches, Laia Halec, Gordana Pawlita, Michael Wain, Gerard Vincent Salas Vailen, José Santos Azike, Jerome E. Jenkins, David Sanjosé Llongueras, Silvia de Quint, Wim Bosch, F. Xavier |
Keywords: | Càncer Papil·lomavirus Cancer Papillomaviruses |
Issue Date: | 1-Apr-2017 |
Publisher: | Nature Publishing |
Abstract: | Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role. Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. LCM-PCR was used to localise HPV DNA to tumour cells. P16(INK4a)and p53 expression were studied by immunohistochemistry. Results: In three warty or basaloid SCSC HPV16-DNA and E6*I-mRNA were detected. LCM-PCR confirmed HPV16 was in p16(INK4a)-positive malignant cells. However, of three usual-type SCSC, all were HPV-negative and two expressed p53 protein but not p16(INK4a). Conclusions: Human papillomavirus 16 was present in tumour cells and oncogenically active in basaloid and warty SCSC, whereas usual SCSC was HPV-negative and showed immunostaining, suggesting p53 mutation. The dual pathways of oncogenesis and relation between histological type of SCSC and HPV are similar to that in penile cancers. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/bjc.2017.74 |
It is part of: | British Journal of Cancer, 2017, vol. 116, p. 1218-1222 |
URI: | http://hdl.handle.net/2445/124410 |
Related resource: | https://doi.org/10.1038/bjc.2017.74 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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