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http://hdl.handle.net/2445/124828
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DC Field | Value | Language |
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dc.contributor.author | Antelo, Marina | - |
dc.contributor.author | Balaguer Prunés, Francesc | - |
dc.contributor.author | Shia, Jinru | - |
dc.contributor.author | Shen, Yan | - |
dc.contributor.author | Hur, Keun | - |
dc.contributor.author | Moreira Ruiz, Leticia | - |
dc.contributor.author | Cuatrecasas Freixas, Miriam | - |
dc.contributor.author | Bujanda, Luis | - |
dc.contributor.author | Giraldez, Maria Dolores | - |
dc.contributor.author | Takahashi, Masanobu | - |
dc.contributor.author | Cabanne, Ana | - |
dc.contributor.author | Barugel, Mario Edmundo | - |
dc.contributor.author | Arnold, Mildred | - |
dc.contributor.author | Roca, Enrique Luis | - |
dc.contributor.author | Andreu, Montserrat | - |
dc.contributor.author | Castellví Bel, Sergi | - |
dc.contributor.author | Llor, Xavier | - |
dc.contributor.author | Jover, Rodrigo | - |
dc.contributor.author | Castells Garangou, Antoni | - |
dc.contributor.author | Boland, C. Richard | - |
dc.contributor.author | Goel, Ajay | - |
dc.date.accessioned | 2018-09-26T10:30:03Z | - |
dc.date.available | 2018-09-26T10:30:03Z | - |
dc.date.issued | 2012-09-25 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124828 | - |
dc.description.abstract | Objective Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized as independent factors for increased cancer-related mortality. The methylation status of LINE-1 elements in early-onset CRC has not been analyzed previously. Design We analyzed 343 CRC tissues and 32 normal colonic mucosa samples, including 2 independent cohorts of CRC diagnosed ≤50 years old (n = 188), a group of sporadic CRC >50 years (MSS n = 89; MSI n = 46), and a group of Lynch syndrome CRCs (n = 20). Tumor mismatch repair protein expression, microsatellite instability status, LINE-1 and MLH1 methylation, somatic BRAF V600E mutation, and germline MUTYH mutations were evaluated. Results Mean LINE-1 methylation levels (±SD) in the five study groups were early-onset CRC, 56.6% (8.6); sporadic MSI, 67.1% (5.5); sporadic MSS, 65.1% (6.3); Lynch syndrome, 66.3% (4.5) and normal mucosa, 76.5% (1.5). Early-onset CRC had significantly lower LINE-1 methylation than any other group (p<0.0001). Compared to patients with <65% LINE-1 methylation in tumors, those with ≥65% LINE-1 methylation had significantly better overall survival (p = 0.026, log rank test). Conclusions LINE-1 hypomethylation constitutes a potentially important feature of early-onset CRC, and suggests a distinct molecular subtype. Further studies are needed to assess the potential of LINE-1 methylation status as a prognostic biomarker for young people with CRC. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0045357 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 9, p. e45357 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0045357 | - |
dc.rights | cc-by (c) Antelo, Marina et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Epidemiologia genètica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Cancer | - |
dc.subject.other | Genetic epidemiology | - |
dc.title | A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 635325 | - |
dc.date.updated | 2018-09-26T10:30:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23049789 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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