Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124831
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Takahashi, Masanobu | - |
dc.contributor.author | Cuatrecasas Freixas, Miriam | - |
dc.contributor.author | Balaguer Prunés, Francesc | - |
dc.contributor.author | Hur, Keun | - |
dc.contributor.author | Toiyama, Yuji | - |
dc.contributor.author | Castells Garangou, Antoni | - |
dc.contributor.author | Boland, C. Richard | - |
dc.contributor.author | Goel, Ajay | - |
dc.date.accessioned | 2018-09-26T10:43:32Z | - |
dc.date.available | 2018-09-26T10:43:32Z | - |
dc.date.issued | 2012-10-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124831 | - |
dc.description.abstract | Aim: Development of robust prognostic and/or predictive biomarkers in patients with colorectal cancer (CRC) is imperative for advancing treatment strategies for this disease. We aimed to determine whether expression status of certain miRNAs might have prognostic/predictive value in CRC patients treated with conventional cytotoxic chemotherapies. Methods: We studied a cohort of 273 CRC specimens from stage II/III patients treated with 5-fluorouracil-based adjuvant chemotherapy and stage IV patients subjected to 5-fluorouracil and oxaliplatin-based chemotherapy. In a screening set (n = 44), 13 of 21 candidate miRNAs were successfully quantified by multiplex quantitative RT-PCR. In the validation set comprising of the entire patient cohort, miR-148a expression status was assessed by quantitative RT-PCR, and its promoter methylation was quantified by bisulfite pyrosequencing. Lastly, we analyzed the associations between miR-148a expression and patient survival. Results: Among the candidate miRNAs studied, miR-148a expression was most significantly down-regulated in advanced CRC tissues. In stage III and IV CRC, low miR-148a expression was associated with significantly shorter disease free-survival (DFS), a worse therapeutic response, and poor overall survival (OS). Furthermore, miR-148a methylation status correlated inversely with its expression, and was associated with worse survival in stage IV CRC. In multivariate analysis, miR-148a expression was an independent prognostic/predictive biomarker for advanced CRC patients (DFS in stage III, low vs. high expression, HR 2.11; OS in stage IV, HR 1.93). Discussion: MiR-148a status has a prognostic/predictive value in advanced CRC patients treated with conventional chemotherapy, which has important clinical implications in improving therapeutic strategies and personalized management of this malignancy. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0046684 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 10, p. e46684 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0046684 | - |
dc.rights | cc-by (c) Takahashi, Masanobu et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Genètica humana | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Human genetics | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Cancer | - |
dc.title | The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 635324 | - |
dc.date.updated | 2018-09-26T10:43:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23056401 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
635324.pdf | 467.55 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License