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http://hdl.handle.net/2445/124909
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DC Field | Value | Language |
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dc.contributor.author | Zamora, Ana | - |
dc.contributor.author | Gandioso, Albert | - |
dc.contributor.author | Massaguer i Vall-llovera, Anna | - |
dc.contributor.author | Buenestado, Silvia | - |
dc.contributor.author | Calvis, Carme | - |
dc.contributor.author | Hernández, José Luis | - |
dc.contributor.author | Mitjans, Francesc | - |
dc.contributor.author | Rodríguez, Venancio | - |
dc.contributor.author | Ruiz, José | - |
dc.contributor.author | Marchán Sancho, Vicente | - |
dc.date.accessioned | 2018-09-28T08:26:46Z | - |
dc.date.available | 2019-09-06T05:10:17Z | - |
dc.date.issued | 2018-09-06 | - |
dc.identifier.issn | 1860-7179 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124909 | - |
dc.description.abstract | A novel conjugate between a cyclometalated platinum(II) complex with dual antiangiogenic and antitumor activity and a cyclic peptide containing the RGD sequence (-Arg-Gly-Asp-) has been synthesized by combining solid- and solution-phase methodologies. Although peptide conjugation rendered a non-cytotoxic compound in all tested tumor cell lines (± αV β3 and αV β5 integrin receptors), the antiangiogenic activity of the Pt-c(RGDfK) conjugate in human umbilical vein endothelial cells at sub-cytotoxic concentrations opens the way to the design of a novel class of angiogenesis inhibitors through conjugation of metallodrugs with high antiangiogenic activity to cyclic RGD-containing peptides or peptidomimetic analogues. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/cmdc.201800282 | - |
dc.relation.ispartof | ChemMedChem, 2018, vol. 13, num. 17, p. 1755-1762 | - |
dc.relation.uri | https://doi.org/10.1002/cmdc.201800282 | - |
dc.rights | (c) Wiley-VCH, 2018 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Compostos organometàl·lics | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Cancer | - |
dc.subject.other | Peptides | - |
dc.subject.other | Organometallic compounds | - |
dc.title | Toward angiogenesis inhibitors based on the conjugation of organometallic platinum(II) complexes to RGD peptides | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 682200 | - |
dc.date.updated | 2018-09-28T08:26:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29932312 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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682200.pdf | 867.68 kB | Adobe PDF | View/Open |
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