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Title: Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
Author: Cobo Cobo, María Teresa
Kacerovsky, Marian
Palacio i Riera, Montserrat
Hornychova, Helena
Hougaard, David M.
Skogstrand, Kristin
Jacobsson, Bo
Keywords: Inflamació
Complicacions en l'embaràs
Complications of pregnancy
Issue Date: 20-Aug-2012
Publisher: Public Library of Science (PLoS)
Abstract: Background To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM). Methodology/Principal Finding A prospective cohort study was performed in 107 women with PPROM between 23.0 and 36.6 weeks of gestational age. Twenty-six proteins were assayed by multiple immunoassay in amniotic fluid. The policy for PPROM in Czech Republic is active, and 90% of the women were delivered within 96 hours of membrane rupture. Histopathological placental findings were evaluated based on the Salafia classification. Data were analyzed in four subgroups of population according to the presence of MIAC and/or HCA. Results were stratified by gestational age at PPROM (< or ≥34.0 weeks). The rates of MIAC and HCA were 44% and 57%, respectively. Regardless of gestational age at PPROM, intra-amniotic inflammatory response was higher when MIAC and HCA were both present. There were no differences in the intra-amniotic inflammatory response between women with MIAC or HCA alone and women without infection. Conclusion A higher intra-amniotic inflammatory response was identified when both HCA and MIAC were detected.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 8, p. e43677
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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