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http://hdl.handle.net/2445/125144
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DC Field | Value | Language |
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dc.contributor.author | Jalan, Rajiv | - |
dc.contributor.author | Pavesi, Marco | - |
dc.contributor.author | Saliba, Faouzi | - |
dc.contributor.author | Amorós, Àlex | - |
dc.contributor.author | Fernández, Javier | - |
dc.contributor.author | Holland-Fischer, Peter | - |
dc.contributor.author | Sawhney, Rohit | - |
dc.contributor.author | Mookerjee, Rajeshwar P. | - |
dc.contributor.author | Caraceni, Paolo | - |
dc.contributor.author | Moreau, Richard | - |
dc.contributor.author | Ginès i Gibert, Pere | - |
dc.contributor.author | Durand, François | - |
dc.contributor.author | Angeli, Paolo | - |
dc.contributor.author | Alessandria, Carlo | - |
dc.contributor.author | Laleman, Wim | - |
dc.contributor.author | Trebicka, Jonel | - |
dc.contributor.author | Samuel, Didier | - |
dc.contributor.author | Zeuzem, Stefan | - |
dc.contributor.author | Gustot, Thierry | - |
dc.contributor.author | Gerbes, Alexander L. | - |
dc.contributor.author | Wendon, Julia | - |
dc.contributor.author | Bernardi, Mauro | - |
dc.contributor.author | Arroyo, Vicente | - |
dc.date.accessioned | 2018-10-08T14:28:28Z | - |
dc.date.available | 2018-10-08T14:28:28Z | - |
dc.date.issued | 2015-04-30 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125144 | - |
dc.description.abstract | BACKGROUND & AIMS: Cirrhotic patients with acute decompensation frequently develop acute-on-chronic liver failure (ACLF), which is associated with high mortality rates. Recently, a specific score for these patients has been developed using the CANONIC study database. The aims of this study were to develop and validate the CLIF-C AD score, a specific prognostic score for hospitalised cirrhotic patients with acute decompensation (AD), but without ACLF, and to compare this with the Child-Pugh, MELD, and MELD-Na scores. METHODS: The derivation set included 1016 CANONIC study patients without ACLF. Proportional hazards models considering liver transplantation as a competing risk were used to identify score parameters. Estimated coefficients were used as relative weights to compute the CLIF-C ADs. External validation was performed in 225 cirrhotic AD patients. CLIF-C ADs was also tested for sequential use. RESULTS: Age, serum sodium, white-cell count, creatinine and INR were selected as the best predictors of mortality. The C-index for prediction of mortality was better for CLIF-C ADs compared with Child-Pugh, MELD, and MELD-Nas at predicting 3- and 12-month mortality in the derivation, internal validation and the external dataset. CLIF-C ADs improved in its ability to predict 3-month mortality using data from days 2, 3-7, and 8-15 (C-index: 0.72, 0.75, and 0.77 respectively). CONCLUSIONS: The new CLIF-C ADs is more accurate than other liver scores in predicting prognosis in hospitalised cirrhotic patients without ACLF. CLIF-C ADs therefore may be used to identify a high-risk cohort for intensive management and a low-risk group that may be discharged early. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.jhep.2014.11.012 | - |
dc.relation.ispartof | Journal of Hepatology, 2015, vol. 62, num. 4, p. 831-840 | - |
dc.relation.uri | https://doi.org/10.1016/j.jhep.2014.11.012 | - |
dc.rights | (c) Elsevier, 2015 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Prognosis | - |
dc.title | The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 644976 | - |
dc.date.updated | 2018-10-08T14:28:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25463539 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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644976.pdf | 387.24 kB | Adobe PDF | View/Open |
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