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http://hdl.handle.net/2445/125347
Title: | Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England |
Author: | Andrew, Angeline S. Caller, Tracie A. Tandan, Rup Duell, Eric J. Henegan, Patricia L. Field, Nicholas Bradley, Walter G. Stommel, Elijah W. |
Keywords: | Esclerosi lateral amiotròfica Factors de risc en les malalties Amyotrophic lateral sclerosis Risk factors in diseases |
Issue Date: | 1-Jan-2017 |
Publisher: | Karger |
Abstract: | Background: Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective: To evaluate environmental and occupational exposures as risk factors for sporadic ALS. Methods: We performed a case control study of ALS among residents of New England, USA. The analysis compared questionnaire responses from 295 patients with a confirmed ALS diagnosis to those of 225 controls without neurodegenerative illness. Results: Self-reported job-or hobby-related exposure to one or more chemicals, such as pesticides, solvents, or heavy metals, increased the risk of ALS (adjusted OR 2.51; 95% CI 1.64-3.89). Industries with a higher toxicant exposure potential (construction, manufacturing, mechanical, military, or painting) were associated with an elevated occupational risk (adjusted OR 3.95; 95% CI 2.04-8.30). We also identified increases in the risk of ALS associated with frequent participation in water sports, particularly waterskiing (adjusted OR 3.89; 95% C11.97-8.44). Occupation and waterskiing both retained independent statistical significance in a composite model containing age, gender, and smoking status. Conclusions: Our study contributes to a growing body of literature implicating occupational-and hobby-related toxicant exposures in ALS etiology. These epidemiologic study results also provide motivation for future evaluation of water-body-related risk factors. (C) 2017 S. Karger AG, Basel |
Note: | Versió postprint del document publicat a: https://doi.org/10.1159/000453359 |
It is part of: | Neurodegenerative Diseases, 2017, Vol. 17, Issue 2-3, P. 110-116 |
URI: | http://hdl.handle.net/2445/125347 |
Related resource: | https://doi.org/10.1159/000453359 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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AndrewAS.pdf | 85.09 kB | Adobe PDF | View/Open |
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