Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/125365
Title: | Menstrual And Reproductive Factors, Hormone Use, And Risk Of Pancreatic Cancer: Analysis From The International Pancreatic Cancer Case-control Consortium (Panc4) |
Author: | Luján Barroso, Leila Zhang, Wei Olson, Sara H. Gao, Yu-Tang Yu, Herbert Baghurst, Peter A. Bracci, Paige M. Bueno de Mesquita, H. Bas Foretová, Lenka Gallinger, Steven Holcátová, Ivana Janout, Vladimir Ji, Bu-Tian Kurtz, Robert C. Vecchia, Carlo La Lagiou, Pagona Li, Donghui Miller, Anthony B. Serraino, Diego Zatoński, Witold Risch, Harvey A. Duell, Eric J. |
Keywords: | Càncer de pàncrees Menstruació Reproducció Pancreas cancer Menstruation Reproduction |
Issue Date: | 1-Nov-2016 |
Publisher: | Lippincott Williams & Wilkins |
Abstract: | Objectives: We aimed to evaluate the relation between menstrual and reproductive factors, exogenous hormones, and risk of pancreatic cancer (PC). Methods: Eleven case-control studies within the International Pancreatic Cancer Case-control Consortium took part in the present study, including in total 2838 case and 4748 control women. Pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a 2-step logistic regression model and adjusting for relevant covariates. Results: An inverse OR was observed in women who reported having had hysterectomy (ORyesvs.no, 0.78; 95% CI, 0.67-0.91), remaining significant in postmenopausal women and never-smoking women, adjusted for potential PC confounders. A mutually adjusted model with the joint effect for hormone replacement therapy (HRT) and hysterectomy showed significant inverse associations with PC in women who reported having had hysterectomy with HRT use (OR, 0.64; 95% CI, 0.48-0.84). Conclusions: Our large pooled analysis suggests that women who have had a hysterectomy may have reduced risk of PC. However, we cannot rule out that the reduced risk could be due to factors or indications for having had a hysterectomy. Further investigation of risk according to HRT use and reason for hysterectomy may be necessary. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1097/MPA.0000000000000635 |
It is part of: | Pancreas, 2016, vol. 45, num. 10, p. 1401-1410 |
URI: | http://hdl.handle.net/2445/125365 |
Related resource: | https://doi.org/10.1097/MPA.0000000000000635 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Lujan-BarrosoL.pdf | 570.8 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.