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DC Field | Value | Language |
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dc.contributor.author | Pereira, Licia P. | - |
dc.contributor.author | Köhler, Cristiano A. | - |
dc.contributor.author | Sousa, Rafael T. | - |
dc.contributor.author | Solmi, Marco | - |
dc.contributor.author | Freitas, Bárbara P. de | - |
dc.contributor.author | Fornaro, Michele | - |
dc.contributor.author | Machado-Vieira, Rodrigo | - |
dc.contributor.author | Miskowiak, Kamilla W. | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.contributor.author | Veronese, Nicola | - |
dc.contributor.author | Stubbs, Brendon | - |
dc.contributor.author | Carvalho, André F. | - |
dc.date.accessioned | 2018-10-16T15:14:44Z | - |
dc.date.available | 2019-07-01T05:10:14Z | - |
dc.date.issued | 2017-08-01 | - |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125372 | - |
dc.description.abstract | Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach | - |
dc.format.extent | 61 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.neubiorev.2017.05.002 | - |
dc.relation.ispartof | Neuroscience and Biobehavioral Reviews, 2017, vol. 79, p. 87-109 | - |
dc.relation.uri | https://doi.org/10.1016/j.neubiorev.2017.05.002 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Cervell | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Brain | - |
dc.title | The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 671501 | - |
dc.date.updated | 2018-10-16T15:14:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28479278 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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671501.pdf | 973.01 kB | Adobe PDF | View/Open |
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