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http://hdl.handle.net/2445/125584
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DC Field | Value | Language |
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dc.contributor.author | Bu, Pengcheng | - |
dc.contributor.author | Wang, Lihua | - |
dc.contributor.author | Chen, Kai-Yuan | - |
dc.contributor.author | Rakhilin, Nikolai | - |
dc.contributor.author | Sun, Jian | - |
dc.contributor.author | Closa, Adrià | - |
dc.contributor.author | Tung, Kuei-Ling | - |
dc.contributor.author | King, Sarah | - |
dc.contributor.author | Kristine Varanko, Anastasia | - |
dc.contributor.author | Xu, Yitian | - |
dc.contributor.author | Huan Chen, Joyce | - |
dc.contributor.author | Zessin, Amelia S. | - |
dc.contributor.author | Shealy, James | - |
dc.contributor.author | Cummings, Bethany | - |
dc.contributor.author | Hsu, David | - |
dc.contributor.author | Lipkin, Steven M. | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Gümüş, Zeynep H. | - |
dc.contributor.author | Shen, Xiling | - |
dc.date.accessioned | 2018-10-24T11:39:18Z | - |
dc.date.available | 2018-10-24T11:39:18Z | - |
dc.date.issued | 2015-04-15 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125584 | - |
dc.description.abstract | As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal cancer (CRC) metastasis and forms a positive feedback loop with TGF-β signalling. miR-1269a is upregulated in late-stage CRCs, and long-term monitoring of 100 stage II CRC patients revealed that miR-1269a expression in their surgically removed primary tumours is strongly associated with risk of CRC relapse and metastasis. Consistent with clinical observations, miR-1269a significantly increases the ability of CRC cells to invade and metastasize in vivo. TGF-β activates miR-1269 via Sox4, while miR-1269a enhances TGF-β signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop. Our findings suggest that miR-1269a is a potential marker to inform adjuvant chemotherapy decisions for CRC patients and a potential therapeutic target to deter metastasis. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/ncomms7879. | - |
dc.relation.ispartof | Nature Communications, 2015, vol. 15, num. 6, p. 6879 | - |
dc.relation.uri | https://doi.org/10.1038/ncomms7879. | - |
dc.rights | cc-by (c) Bu, Pengcheng et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Quimioteràpia del càncer | - |
dc.subject.classification | Metàstasi | - |
dc.subject.other | Cancer | - |
dc.subject.other | Cancer chemotherapy | - |
dc.subject.other | Metastasis | - |
dc.title | miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 660205 | - |
dc.date.updated | 2018-10-24T11:39:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25872451 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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660205.pdf | 3.16 MB | Adobe PDF | View/Open |
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