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http://hdl.handle.net/2445/125607
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DC Field | Value | Language |
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dc.contributor.author | Sepúlveda Martínez, Álvaro | - |
dc.contributor.author | Rodríguez López, Mérida | - |
dc.contributor.author | Paz y Miño, Fernanda | - |
dc.contributor.author | Casu, Giulia | - |
dc.contributor.author | Crovetto, Francesca | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.date.accessioned | 2018-10-24T15:46:28Z | - |
dc.date.available | 2019-09-11T05:10:18Z | - |
dc.date.issued | 2018-09-11 | - |
dc.identifier.issn | 0960-7692 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125607 | - |
dc.description.abstract | Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p<0.001) and higher prevalence of SGA (40.3% vs. 16.3%; p=0.001) and placental mediated disease (43.1% vs. 17.5%; p=0.001). After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. Conclusions: Our data provides evidence suggesting a transgenerational transmission of SGA highlighting the importance of public health strategies for preventing intrauterine growth impairment. | - |
dc.format.extent | 28 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/uog.20119 | - |
dc.relation.ispartof | Ultrasound in Obstetrics & Gynecology, 2018 | - |
dc.relation.uri | https://doi.org/10.1002/uog.20119 | - |
dc.rights | (c) International Society of Ultrasound in Obstetrics & Gynecology (ISUOG), 2018 | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Creixement fetal | - |
dc.subject.classification | Medicina prenatal | - |
dc.subject.other | Fetal growth | - |
dc.subject.other | Prenatal medicine | - |
dc.title | Transgenerational transmission of small for gestational age | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 682661 | - |
dc.date.updated | 2018-10-24T15:46:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30207012 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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File | Description | Size | Format | |
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682661.pdf | 840.82 kB | Adobe PDF | View/Open |
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