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http://hdl.handle.net/2445/125691
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DC Field | Value | Language |
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dc.contributor.author | Fernández Dueñas, Víctor | - |
dc.contributor.author | Taura, Jaume | - |
dc.contributor.author | Cottet, Martin | - |
dc.contributor.author | Gómez Soler, Maricel | - |
dc.contributor.author | López-Cano, Marc | - |
dc.contributor.author | Ledent, Catherine | - |
dc.contributor.author | Watanabe, Masahiko | - |
dc.contributor.author | Trinquet, Eric | - |
dc.contributor.author | Pin, Jean-Philippe | - |
dc.contributor.author | Luján, Rafael | - |
dc.contributor.author | Durroux, Thierry | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2018-10-29T11:09:34Z | - |
dc.date.available | 2018-10-29T11:09:34Z | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 1754-8403 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125691 | - |
dc.description.abstract | Parkinson's disease (PD) is a dopaminergic-related pathology in which functioning of the basal ganglia is altered. It has been postulated that a direct receptor-receptor interaction - i.e. of dopamine D-2 receptor (D2R) with adenosine A(2A) receptor (A(2A)R) (forming D2R-A(2A)R oligomers) - finely regulates this brain area. Accordingly, elucidating whether the pathology prompts changes to these complexes could provide valuable information for the design of new PD therapies. Here, we first resolved a long-standing question concerning whether D2R-A(2A)R assembly occurs in native tissue: by means of different complementary experimental approaches (i.e. immunoelectron microscopy, proximity ligation assay and TR-FRET), we unambiguously identified native D2R-A(2A)R oligomers in rat striatum. Subsequently, we determined that, under pathological conditions (i.e. in a rat PD model), D2R-A(2A)R interaction was impaired. Collectively, these results provide definitive evidence for alteration of native D2R-A(2A)R oligomers in experimental parkinsonism, thus conferring the rationale for appropriate oligomer-based PD treatments. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The Company of Biologists | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1242/dmm.018143 | - |
dc.relation.ispartof | Disease Models & Mechanisms, 2015, vol. 8, num. 1, p. 57-63 | - |
dc.relation.uri | https://doi.org/10.1242/dmm.018143 | - |
dc.rights | cc-by (c) Fernández Dueñas, Víctor et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.classification | Adenosina | - |
dc.subject.classification | Dopamina | - |
dc.subject.other | Parkinson's disease | - |
dc.subject.other | Adenosine | - |
dc.subject.other | Dopamine | - |
dc.title | Untangling dopamine-adenosine receptor assembly in experimental parkinsonism in rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 644646 | - |
dc.date.updated | 2018-10-29T11:09:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25398851 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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644646.pdf | 1.14 MB | Adobe PDF | View/Open |
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