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Title: A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort
Author: Terry, Kathryn L.
Schock, Helena
Fortner, Renée T.
Hüsing, Anika
Fichorova, Raina N.
Yamamoto, Hidemi S.
Vitonis, Allison F.
Johnson, Theron
Overvad, Kim
Tjønneland, Anne
Boutron-Ruault, Marie-Christine
Mesrine, Sylvie
Severi, Gianluca
Dossus, Laure
Rinaldi, Sabina
Boeing, Heiner
Benetou, Vassiliki
Lagiou, Pagona
Trichopoulou, Antonia
Krogh, Vittorio
Kuhn, Elisabetta
Panico, Salvatore
Bueno de Mesquita, H. Bas
Onland-Moret, N. Charlotte
Peeters, Petra H. M.
Torhild Gram, Inger
Weiderpass, Elisabete
Duell, Eric J.
Sánchez, María José
Ardanaz, Eva
Etxezarreta, Nerea
Navarro, Carmen
Idahl, Annika
Lundin, Eva
Jirström, Karin
Manjer, Jonas
Wareham, Nicholas J.
Khaw, Kay-Tee
Smith Byrne, Karl
Travis, Ruth C.
Gunter, Marc J.
Merritt, Melissa A.
Riboli, Elio
Cramer, Daniel W.
Kaaks, Rudolf
Keywords: Càncer d'ovari
Marcadors bioquímics
Ovarian cancer
Biochemical markers
Issue Date: 15-Sep-2016
Publisher: American Association for Cancer Research
Abstract: Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate earlydetection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis. Results: We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker. Conclusions: CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases. (C) 2016 AACR.
Note: Versió postprint del document publicat a:
It is part of: Clinical Cancer Research, 2016, vol. 22, num. 18, p. 4664-4675
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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