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http://hdl.handle.net/2445/125709
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DC Field | Value | Language |
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dc.contributor.author | Saumell, Sílvia | - |
dc.contributor.author | Solé Ristol, Francesc | - |
dc.contributor.author | Arenillas Rocha, Leonor | - |
dc.contributor.author | Montoro, Julia | - |
dc.contributor.author | Valcárcel, David | - |
dc.contributor.author | Pedro, Carme | - |
dc.contributor.author | Sanzo, Carmen | - |
dc.contributor.author | Luño, Elisa | - |
dc.contributor.author | Giménez, Teresa | - |
dc.contributor.author | Arnan, Montserrat | - |
dc.contributor.author | Pomares, Helena | - |
dc.contributor.author | Paz, Raquel de | - |
dc.contributor.author | Arrizabalaga, Beatriz | - |
dc.contributor.author | Jerez, Andrés | - |
dc.contributor.author | Marténez, Ana B. | - |
dc.contributor.author | Sánchez Castro, Judith | - |
dc.contributor.author | Rodríguez Gambarte, Juan D. | - |
dc.contributor.author | Raya, José Maria | - |
dc.contributor.author | Ríos, Eduardo | - |
dc.contributor.author | Rodríguez Rivera, María | - |
dc.contributor.author | Espinet Solà, Blanca | - |
dc.contributor.author | Florensa, Lourdes | - |
dc.date.accessioned | 2018-10-29T14:37:35Z | - |
dc.date.available | 2018-10-29T14:37:35Z | - |
dc.date.issued | 2015-06-12 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125709 | - |
dc.description.abstract | Isolated trisomy 8 is not considered presumptive evidence of myelodysplastic syndrome (MDS) in cases without minimal morphological criteria. One reason given is that trisomy 8 (+8) can be found as a constitutional mosaicism (cT8M). We tried to clarify the incidence of cT8M in myeloid neoplasms, specifically in MDS, and the diagnostic value of isolated +8 in MDS. Twenty-two MDS and 10 other myeloid neoplasms carrying +8 were studied. Trisomy 8 was determined in peripheral blood by conventional cytogenetics (CC) and on granulocytes, CD3+ lymphocytes and oral mucosa cells by fluorescence in situ hybridization (FISH). In peripheral blood CC, +8 was seen in 4/32 patients. By FISH, only one patient with chronic myelomonocytic leukemia showed +8 in all cell samples and was interpreted as a cT8M. In our series +8 was acquired in all MDS. Probably, once discarded cT8M by FISH from CD3+ lymphocytes and non-hematological cells, +8 should be considered with enough evidence to MDS. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0129375 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 6, p. e0129375 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0129375 | - |
dc.rights | cc by (c) Saumell et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia mieloide | - |
dc.subject.classification | Limfòcits | - |
dc.subject.other | Myeloid leukemia | - |
dc.subject.other | Lymphocytes | - |
dc.title | Trisomy 8, A Cytogenetic Abnormality In Myelodysplastic Syndromes, Is Constitutional Or Not? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:30:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26066831 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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SaumellS.pdf | 184.85 kB | Adobe PDF | View/Open |
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