Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/125912
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wilson, Wyndham H. | - |
dc.contributor.author | Bromberg, Jacoline E.C. | - |
dc.contributor.author | Stetler-Stevenson, Maryalice | - |
dc.contributor.author | Steinberg, Seth M. | - |
dc.contributor.author | Martin Martin, Lourdes | - |
dc.contributor.author | Muñiz, Carmen | - |
dc.contributor.author | Sancho, Juan Manuel | - |
dc.contributor.author | Caballero García, María Dolores | - |
dc.contributor.author | Davidis, Marjan A. | - |
dc.contributor.author | Brooimans, Rik A. | - |
dc.contributor.author | Sánchez González, Blanca | - |
dc.contributor.author | Salar, Antonio | - |
dc.contributor.author | González Barca, Eva | - |
dc.contributor.author | Ribera, Josep Maria | - |
dc.contributor.author | Shovlin, Margaret | - |
dc.contributor.author | Filie, Armando | - |
dc.contributor.author | Dunleavy, Kieron | - |
dc.contributor.author | Mehrling, Thomas | - |
dc.contributor.author | Spina, Michele | - |
dc.contributor.author | Orfao, Alberto | - |
dc.date.accessioned | 2018-11-08T14:26:48Z | - |
dc.date.available | 2018-11-08T14:26:48Z | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125912 | - |
dc.description.abstract | The benefit of intrathecal therapy and systemic rituximab on the outcome of diffuse large B-cell lymphoma at risk of central nervous system disease is controversial. Furthermore, the effect of intrathecal treatment and rituximab in diffuse large B-cell and Burkitt lymphoma with occult leptomeningeal disease detected by flow cytometry at diagnosis is unknown. Untreated diffuse large B-cell (n=246) and Burkitt (n=80) lymphoma at clinical risk of central nervous system disease and having had pre-treatment cerebrospinal fluid were analyzed by flow cytometry and cytology. Spinal fluid involvement was detected by flow cytometry alone (occult) in 33 (13%) diffuse large B-cell and 9 (11%) Burkitt lymphoma patients, and detected by cytology in 11 (4.5%) and 5 (6%) patients, respectively. Diffuse large B-cell lymphoma with occult spinal fluid involvement had poorer survival (P=0.0001) and freedom from central nervous system relapse (P<0.0001) compared to negative cases. Burkitt lymphoma with occult spinal fluid involvement had an inferior freedom from central nervous system relapse (P=0.026) but not survival. The amount of intrathecal chemotherapy was quantitatively associated with survival in diffuse large B-cell lymphoma with (P=0.02) and without (P=0.001) occult spinal fluid involvement. However, progression of systemic disease and not control of central nervous system disease was the principal cause of treatment failure. In diffuse large B-cell lymphoma, systemic rituximab was associated with improved freedom from central nervous system relapse (P=0.003) but not with survival. Our results suggest that patients at risk of central nervous system disease should be evaluated by flow cytometry and that intrathecal prophylaxis/therapy is beneficial. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2013.101741 | - |
dc.relation.ispartof | Haematologica, 2014, vol. 99, num. 7, p. 1228-1235 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2013.101741 | - |
dc.rights | (c) Ferrata Storti Foundation, 2014 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Citometria de fluxe | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | Flow cytometry | - |
dc.title | Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 679857 | - |
dc.date.updated | 2018-11-08T14:26:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24727817 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
679857.pdf | 552.6 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.