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http://hdl.handle.net/2445/125927
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DC Field | Value | Language |
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dc.contributor.author | Titulaer, Maarten J. | - |
dc.contributor.author | Höftberger, Romana | - |
dc.contributor.author | Iizuka, Takahiro | - |
dc.contributor.author | Leypoldt, Frank | - |
dc.contributor.author | McCracken, Lindsey | - |
dc.contributor.author | Cellucci, Tania | - |
dc.contributor.author | Benson, Leslie A. | - |
dc.contributor.author | Shu, Huidy | - |
dc.contributor.author | Irioka, Takashi | - |
dc.contributor.author | Hirano, Makito | - |
dc.contributor.author | Singh, Gagandeep | - |
dc.contributor.author | Cobo Calvo, Álvaro | - |
dc.contributor.author | Kaida, Kenichi | - |
dc.contributor.author | Morales, Pamela S. | - |
dc.contributor.author | Wirtz, Paul W. | - |
dc.contributor.author | Yamamoto, Tomotaka | - |
dc.contributor.author | Reindl, Markus | - |
dc.contributor.author | Rosenfeld, Myrna R. | - |
dc.contributor.author | Graus Ribas, Francesc | - |
dc.contributor.author | Saiz Hinarejos, Albert | - |
dc.contributor.author | Dalmau Obrador, Josep | - |
dc.date.accessioned | 2018-11-08T15:10:34Z | - |
dc.date.available | 2018-11-08T15:10:34Z | - |
dc.date.issued | 2014-02-11 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125927 | - |
dc.description.abstract | Objective: To report the clinical, radiological, and immunological association of demyelinating disorders with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods: Clinical and radiological analysis was done of a cohort of 691 patients with anti-NMDAR encephalitis. Determination of antibodies to NMDAR, aquaporin-4 (AQP4), and myelin oligodendrocyte glycoprotein (MOG) was performed using brain immunohistochemistry and cell-based assays. Results: Twenty-three of 691 patients with anti-NMDAR encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical features of demyelination. Group 1 included 12 patients in whom anti-NMDAR encephalitis was preceded or followed by independent episodes of neuromyelitis optica (NMO) spectrum disorder (5 cases, 4 anti-AQP4 positive) or brainstem or multifocal demyelinating syndromes (7 cases, all anti-MOG positive). Group 2 included 11 patients in whom anti-NMDAR encephalitis occurred simultaneously with MRI and symptoms compatible with demyelination (5 AQ4 positive, 2 MOG positive). Group 3 (136 controls) included 50 randomly selected patients with typical anti-NMDAR encephalitis, 56 with NMO, and 30 with multiple sclerosis; NMDAR antibodies were detected only in the 50 anti-NMDAR patients, MOG antibodies in 3 of 50 anti-NMDAR and 1 of 56 NMO patients, and AQP4 antibodies in 48 of 56 NMO and 1 of 50 anti-NMDAR patients (p < 0.0001 for all comparisons with Groups 1 and 2). Most patients improved with immunotherapy, but compared with anti-NMDAR encephalitis the demyelinating episodes required more intensive therapy and resulted in more residual deficits. Only 1 of 23 NMDAR patients with signs of demyelination had ovarian teratoma compared with 18 of 50 anti-NMDAR controls (p = 0.011). Interpretation: Patients with anti-NMDAR encephalitis may develop concurrent or separate episodes of demyelinating disorders, and conversely patients with NMO or demyelinating disorders with atypical symptoms (eg, dyskinesias, psychosis) may have anti-NMDAR encephalitis. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/ana.24117 | - |
dc.relation.ispartof | Annals of Neurology, 2014, vol. 75, num. 3, p. 411-428 | - |
dc.relation.uri | https://doi.org/10.1002/ana.24117 | - |
dc.rights | (c) American Neurological Association, 2014 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Encefalitis | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.other | Encephalitis | - |
dc.subject.other | Cell receptors | - |
dc.title | Overlapping demyelinating syndromes and anti-NMDA receptor encephalitis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 654289 | - |
dc.date.updated | 2018-11-08T15:10:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24700511 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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654289.pdf | 993.16 kB | Adobe PDF | View/Open |
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