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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125936
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dc.contributor.authorGarcia i Molleví, David-
dc.contributor.authorAytés Meneses, Álvaro-
dc.contributor.authorBerdiel Acer, Mireia-
dc.contributor.authorPadullés Mosella, Laura-
dc.contributor.authorMartínez Iniesta, María-
dc.contributor.authorSanjuan, Xavier-
dc.contributor.authorSalazar Soler, Ramón-
dc.contributor.authorVillanueva Garatachea, Alberto-
dc.date.accessioned2018-11-09T08:57:41Z-
dc.date.available2018-11-09T08:57:41Z-
dc.date.issued2009-07-08-
dc.identifier.issn1476-4598-
dc.identifier.urihttps://hdl.handle.net/2445/125936-
dc.description.abstractWe isolate and culture carcinoma-associated fibroblasts (CAFs) from primary tumour (CAFpt), CAFs from corresponding synchronous liver metastasis (CAFlm) as well as normal colonic fibroblasts (NCF) from the same patient. From these cultures, conditioned media (CM) was obtained. Culture of a wide panel of colorectal and pancreatic cell lines in CM from CAFlm resulted in overexpression of mRNA PRL-3 and higher overexpression in CAFs than in non-activated fibroblasts. Moreover PRL-3 mRNA expression correlates with expression of alpha-SMA and deposition of collagen fibrils in the stroma. We demonstrate that products secreted by CAFs trigger PRL-3 overexpression in cancer cells. Identification of these factors may contribute to new stroma-targeted therapies for desmoplastic tumours-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherBioMed Central-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/1476-4598-8-46-
dc.relation.ispartofMolecular Cancer, 2009, vol. 8, p. 46-
dc.relation.urihttps://doi.org/10.1186/1476-4598-8-46-
dc.rightscc-by (c) Garcia i Molleví, David et al., 2009-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Ciències Clíniques)-
dc.subject.classificationCàncer-
dc.subject.classificationFibroblasts-
dc.subject.classificationMetàstasi-
dc.subject.otherCancer-
dc.subject.otherFibroblasts-
dc.subject.otherMetastasis-
dc.titlePRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec647792-
dc.date.updated2018-11-09T08:57:41Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid19586538-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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