Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126021
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DC Field | Value | Language |
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dc.contributor.author | Lister, Ryan | - |
dc.contributor.author | Mukamel, Eran A. | - |
dc.contributor.author | Nery, Joseph R. | - |
dc.contributor.author | Urich, Mark | - |
dc.contributor.author | Puddifoot, Clare A. | - |
dc.contributor.author | Johnson, Nicholas D. | - |
dc.contributor.author | Lucero, Jacinta | - |
dc.contributor.author | Huang, Yun | - |
dc.contributor.author | Dwork, Andrew J. | - |
dc.contributor.author | Schultz, Matthew D. | - |
dc.contributor.author | Yu, Miao | - |
dc.contributor.author | Tonti Filippini, Julian | - |
dc.contributor.author | Heyn, Holger | - |
dc.contributor.author | Hu, Shijun | - |
dc.contributor.author | Wu, Joseph C. | - |
dc.contributor.author | Rao, Anjana | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | He, Chuan | - |
dc.contributor.author | Haghighi, Fatemeh G | - |
dc.contributor.author | Sejnowski, Terrence J. | - |
dc.contributor.author | Behrens, M. Margarita | - |
dc.contributor.author | Ecker, Joseph R. | - |
dc.date.accessioned | 2018-11-12T15:37:54Z | - |
dc.date.available | 2018-11-12T15:37:54Z | - |
dc.date.issued | 2013-08-09 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126021 | - |
dc.description.abstract | DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity. | - |
dc.format.extent | 21 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1126/science.1237905 | - |
dc.relation.ispartof | Science, 2013, vol. 341, num. 6146 | - |
dc.relation.uri | https://doi.org/10.1126/science.1237905 | - |
dc.rights | (c) Lister, Ryan et al., 2013 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Aprenentatge | - |
dc.subject.classification | Memòria | - |
dc.subject.other | DNA | - |
dc.subject.other | Learning | - |
dc.subject.other | Memory | - |
dc.title | Global epigenomic reconfiguration during mammalian brain development | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 662695 | - |
dc.date.updated | 2018-11-12T15:37:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23828890 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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662695.pdf | 3.59 MB | Adobe PDF | View/Open |
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