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Title: Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Author: Berndt, Sonja I.
Skibola, Christine F.
Joseph, Vijai
Camp, Nicola J.
Nieters, Alexandra
Wang, Zhaoming
Cozen, Wendy
Monnereau, Alain
Wang, Sophia S.
Kelly, Rachel S.
Lan, Qing
Teras, Lauren R.
Chatterjee, Nilanjan
Chung, Charles C.
Yeager, Meredith
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Birmann, Brenda M.
Armstrong, Bruce K.
Cocco, Pierluigi
Zhang, Yawei
Severi, Gianluca
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Burdette, Laurie
Yuenger, Jeffrey
Hutchinson, Amy
Jacobs, Kevin B.
Call, Timothy G.
Shanafelt, Tait D.
Novak, Anne J.
Kay, Neil E.
Liebow, Mark
Wang, Alice H.
Smedby, Karin E.
Adami, Hans-Olov
Melbye, Mads
Glimelius, Bengt
Chang, Ellen T.
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Jones, Brandt
Diver, W. Ryan
Link, Brian K.
Weiner, George J.
Conde, Lucía
Bracci, Paige M.
Riby, Jacques
Holly, Elizabeth A.
Smith, Martyn T.
Jackson, Rebecca D. J.
Tinker, Lesley F.
Benavente, Yolanda
Becker, Nikolaus
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadié, Marc
McKay, James D.
Staines, Anthony
Keywords: Leucèmia limfocítica crònica
Chronic lymphocytic leukemia
Issue Date: 1-Jan-2013
Publisher: Nature Publishing Group
Abstract: Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
Note: Versió postprint del document publicat a:
It is part of: Nature Genetics, 2013, vol. 8, num. 45, p. 868-876
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ISSN: 1061-4036
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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