Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126022
Title: | Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia |
Author: | Berndt, Sonja I. Skibola, Christine F. Joseph, Vijai Camp, Nicola J. Nieters, Alexandra Wang, Zhaoming Cozen, Wendy Monnereau, Alain Wang, Sophia S. Kelly, Rachel S. Lan, Qing Teras, Lauren R. Chatterjee, Nilanjan Chung, Charles C. Yeager, Meredith Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Birmann, Brenda M. Armstrong, Bruce K. Cocco, Pierluigi Zhang, Yawei Severi, Gianluca Zeleniuch-Jacquotte, Anne Lawrence, Charles Burdette, Laurie Yuenger, Jeffrey Hutchinson, Amy Jacobs, Kevin B. Call, Timothy G. Shanafelt, Tait D. Novak, Anne J. Kay, Neil E. Liebow, Mark Wang, Alice H. Smedby, Karin E. Adami, Hans-Olov Melbye, Mads Glimelius, Bengt Chang, Ellen T. Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Jones, Brandt Diver, W. Ryan Link, Brian K. Weiner, George J. Conde, Lucía Bracci, Paige M. Riby, Jacques Holly, Elizabeth A. Smith, Martyn T. Jackson, Rebecca D. J. Tinker, Lesley F. Benavente, Yolanda Becker, Nikolaus Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadié, Marc McKay, James D. Staines, Anthony |
Keywords: | Leucèmia limfocítica crònica Genòmica Chronic lymphocytic leukemia Genomics |
Issue Date: | 1-Jan-2013 |
Publisher: | Nature Publishing Group |
Abstract: | Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/ng.2652 |
It is part of: | Nature Genetics, 2013, vol. 8, num. 45, p. 868-876 |
URI: | http://hdl.handle.net/2445/126022 |
Related resource: | https://doi.org/10.1038/ng.2652 |
ISSN: | 1061-4036 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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