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Títol: Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE Registry
Autor: Bertoletti, Laurent
Quenet, Sara
Laporte, Silvy
Sahuquillo, Joan Carles
Conget, Francisco
Pedrajas, José María
Martín, Mar
Casado, Ignacio
Riera Mestre, Antoni
Monreal Bosch, Manuel
RIETE investigadors
Matèria: Embòlia pulmonar
Tromboembolisme
Pneumologia
Pronòstic mèdic
Pulmonary embolism
Thromboembolism
Pneumology
Prognosis
Data de publicació: 18-jul-2013
Publicat per: BioMed Central
Resum: Background: Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients. Methods: COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)). Results: Of the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7). Conclusions: COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.
Nota: Reproducció del document publicat a: https://doi.org/10.1186/1465-9921-14-75
És part de: Respiratory Research, 2013, vol. 14, p. 75-83
URI: https://hdl.handle.net/2445/126064
Recurs relacionat: https://doi.org/10.1186/1465-9921-14-75
ISSN: 1465-993X
Apareix en les col·leccions:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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