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Title: Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
Author: Chajès, Véronique
Biessy, Carine
Ferrari, Pietro
Romieu, Isabelle
Freisling, Heinz
Huybrechts, Inge
Scalbert, Augustin
Bueno de Mesquita, H. Bas
Romaguera, Dora
Gunter, Marc J.
Vineis, Paolo
Plambeck Hansen, Camilla
Jakobsen, Marianne Uhre
Clavel-Chapelon, Françoise
Fagherazzi, Guy
Boutron-Ruault, Marie-Christine
Katzke, Verena
Neamat-Allah, Jasmine
Boeing, Heiner
Bachlechner, Ursula
Trichopoulou, Antonia
Naska, Androniki
Orfanos, Philippos
Pala, Valeria
Masala, Giovanna
Mattiello, Amalia
Skeie, Guri
Weiderpass, Elisabete
Agudo, Antonio
Huerta Castaño, José María
Ardanaz, Eva
Sánchez, María José
Dorronsoro, Miren
Quirós, J. Ramón
Johansson, Ingegerd
Winkvist, Anna
Sonestedt, Emily
Key, Timothy J.
Khaw, Kay-Tee
Wareham, Nicholas J.
Peeters, Petra H. M.
Slimani, Nadia
Keywords: Àcids grassos
Marcadors bioquímics
Fatty acids
Biochemical markers
Issue Date: 12-Feb-2015
Publisher: Public Library of Science (PLoS)
Abstract: Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region. Results: In women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss ( OR = 0.82, 95% CI = 0.66- 1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5- year follow- up ( OR = 1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for saturated and cismonounsaturated fatty acids. Conclusions: These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially- produced trans fatty acids.
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It is part of: PLoS One, 2015, vol. 10, num. 2, p. e0118206
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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