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Title: | Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis |
Author: | García Bermúdez, Mercedes López Mejías, Raquel Genre, Fernanda Castañeda, Santos Corrales, Alfonso Llorca Díaz, Javier González Juanatey, Carlos Ubilla, Begoña Miranda-Filloy, José A. Pina, Trinitario Gómez Vaquero, Carmen Rodríguez-Rodríguez, Luis Fernández Gutiérrez, Benjamín Balsa, Alejandro Pascual-Salcedo, Dora López Longo, Francisco J. Carreira, Patricia Blanco, Ricardo Martín, Javier González-Gay, Miguel A. |
Keywords: | Artritis reumatoide Malalties cardiovasculars Rheumatoid arthritis Cardiovascular diseases |
Issue Date: | 1-Jan-2015 |
Publisher: | Hindawi Publishing Corporation |
Abstract: | Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2015/318364 |
It is part of: | BioMed Research International, 2015, |
URI: | http://hdl.handle.net/2445/126169 |
Related resource: | https://doi.org/10.1155/2015/318364 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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