Title: | A genome-wide association study of marginal zone lymphoma shows association to the HLA region |
Author: | Vijai, Joseph Wang, Zhaoming Berndt, Sonja I. Skibola, Christine F. Slager, Susan L. Sanjosé Llongueras, Silvia de Melbye, Mads Glimelius, Bengt Bracci, Paige M. Conde, Lucía Birmann, Brenda M. Diver, W. Ryan Vajdic, Claire M. Armstrong, Bruce K. Kricker, Anne Zheng, Tongzhang Holford, Theodore R. Severi, Gianluca Vineis, Paolo Ferri, Giovanni M. Ricco, Rosalia Miligi, Lucia Clavel, Jacqueline Giovannucci, Edward L. Kraft, Peter Virtamo, Jarmo Smith, Alex Kane, Eleanor Roman, Eve Chiu, Brian C. H. Fraumeni, Joseph F. Wu, Xifeng Cerhan, James R. Offit, Kenneth Chanock, Stephen J. Rothman, Nathaniel Nieters, Alexandra Wang, Sophia S. Brooks-Wilson, Angela R. Lan, Qing Bakker, Paul I. W. de Vermeulen, Roel C. H. Portlock, Carol Ansell, Stephen M. Link, Brian K. Riby, Jacques North, Kari E. Gu, Jian Hjalgrim, Henrik Cozen, Wendy Becker, Nikolaus Teras, Lauren R. Spinelli, John J. Turner, Jenny Zhang, Yawei Purdue, Mark P. Giles, Graham G. Kelly, Rachel S. Zeleniuch-Jacquotte, Anne Ennas, Maria Grazia Monnereau, Alain Bertrand, Kimberly A. Albanes, Demetrius Lightfoot, Tracy Yeager, Meredith Chung, Charles C. Burdett, Laurie Hutchinson, Amy Lawrence, Charles Montalvan, Rebecca Liang, Liming Huang, Jinyan Ma, Baoshan Villano, Danylo J. Maria, Ann Corines, Marina Thomas, Tinu Novak, Anne J. Dogan, Ahmet Liebow, Mark Thompson, Carrie A. Witzig, Thomas E. Habermann, Thomas M. Weiner, George J. Smith, Martyn T. Holly, Elizabeth A. Jackson, Rebecca D. J. Tinker, Lesley F. Ye, Yuanqing Adami, Hans-Olov Smedby, Karin E. Roos, Anneclaire J. De Hartge, Patricia Morton, Lindsay M. Severson, Richard K. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadié, Marc McKay, James D. Staines, Anthony |
Keywords: | Malaltia de Hodgkin Cèl·lules B Hodgkin's disease B cells |
Issue Date: | 8-Jan-2015 |
Publisher: | Nature Publishing Group |
Abstract: | Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/ncomms6751 |
It is part of: | Nature Communications, 2015, vol. 6 |
URI: | http://hdl.handle.net/2445/126171 |
Related resource: | https://doi.org/10.1038/ncomms6751 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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