Please use this identifier to cite or link to this item:
Title: Fat Mass and Obesity-Associated Gene (FTO) in Eating Disorders: Evidence for Association of the rs9939609 Obesity Risk Allele with Bulimia nervosa and Anorexia nervosa
Author: Müller, Timo D.
Greene, Brandon H.
Bellodi, Laura
Cavallini, Maria C.
Cellini, Elena
Bella, Daniela Di
Ehrlich, Stefan
Erzegovesi, Stefano
Estivill, Xavier, 1955-
Fernández Aranda, Fernando
Fichter, Manfred M.
Fleischhaker, Christian
Scherag, Susan
Gratacòs, Mònica
Grallert, Harald
Herpertz Dahlmann, Beate
Herzog, Wolfgang
Illig, Thomas
Lehmkuhl, Ulrike
Nacmias, Benedetta
Ribasés Haro, Marta
Ricca, Valdo
Schäfer, Helmut
Scherag, André
Sorbi, Sandro
Wichmann, H.-Erich
Hebebrand, Johannes
Hinney, Anke
Keywords: Obesitat
Trastorns de la conducta alimentària
Anorèxia nerviosa
Eating disorders
Anorexia nervosa
Issue Date: 27-Jun-2012
Publisher: S. Karger
Abstract: Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001-infinity; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932-infinity; one-sided p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027-1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101-2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN. Copyright (C) 2012 S. Karger GmbH, Freiburg
Note: Reproducció del document publicat a:
It is part of: Obesity Facts, 2012, vol. 5, num. 3, p. 408-419
Related resource:
ISSN: 1662-4025
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
617676.pdf686.51 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons