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Title: Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
Author: López Vicario, Cristina
Rius, Bibiana
Alcaraz-Quiles, José
González Périz, Ana
Martínez Puchol, Ana Isabel
Casulleras, Mireia
Duran Güell, Marta
Ibarzabal, Ainitze
Corcelles Codina, Ricard
Laguna Fernández, Andrés
Bäck, Magnus
Titos Rodríguez, Esther
Clària i Enrich, Joan
Keywords: Teixit adipós
Obesitat mòrbida
Polimorfisme genètic
Adipose tissues
Morbid obesity
Genetic polymorphisms
Issue Date: 16-Nov-2017
Publisher: Nature Publishing Group
Abstract: Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2017, vol. 7, num. 15724
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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