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Title: | Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals |
Author: | López Vicario, Cristina Rius, Bibiana Alcaraz-Quiles, José González Périz, Ana Martínez Puchol, Ana Isabel Casulleras, Mireia Duran Güell, Marta Ibarzabal, Ainitze Corcelles Codina, Ricard Laguna Fernández, Andrés Bäck, Magnus Titos Rodríguez, Esther Clària i Enrich, Joan |
Keywords: | Teixit adipós Obesitat mòrbida Inflamació Comorbiditat Polimorfisme genètic Adipose tissues Morbid obesity Inflammation Comorbidity Genetic polymorphisms |
Issue Date: | 16-Nov-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-15951-z |
It is part of: | Scientific Reports, 2017, vol. 7, num. 15724 |
URI: | http://hdl.handle.net/2445/126199 |
Related resource: | https://doi.org/10.1038/s41598-017-15951-z |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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