Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126297
Title: | Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis |
Author: | Batista, Silvia Maniati, Eleni Reynolds, Louise E. Tavora, Bernardo Lees, Delphine M. Fernandez, Isabelle Elia, George Casanovas i Casanovas, Oriol Lo Celso, Cristina Hagemann, Thorsten Hodivala-Dilke, Kairbaan |
Keywords: | Metàstasi Homeòstasi Metastasis Homeostasis |
Issue Date: | 1-Oct-2014 |
Publisher: | Nature Publishing Group |
Abstract: | Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. Using both experimental and spontaneous metastasis models, we show that genetic ablation of haematopoietic FAK does not affect primary tumour growth but enhances the incidence of metastasis significantly. At a molecular level, haematopoietic FAK deletion results in an increase in PU-1 levels and decrease in GATA-1 levels causing a shift of hematopoietic homeostasis towards a myeloid commitment. The subsequent increase in circulating granulocyte number, with an increase in serum CXCL12 and granulocyte CXCR4 levels, was required for augmented metastasis in mice lacking haematopoietic FAK. Overall our findings provide a mechanism by which haematopoietic FAK controls cancer metastasis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/ncomms6054 |
It is part of: | Nature Communications, 2014, vol. 5 |
URI: | http://hdl.handle.net/2445/126297 |
Related resource: | https://doi.org/10.1038/ncomms6054 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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BatistaS.pdf | 2.79 MB | Adobe PDF | View/Open |
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